Right anterior cingulate cortical volume covaries with respiratory sinus arrhythmia magnitude in combat veterans

Existing data suggest anterior cingulate cortex (ACC) plays a role in autonomic regulation. In persons with posttraumatic stress disorder (PTSD), autonomic regulation appears impaired and smaller mean ACC volume has been reported. This study examined relationships between ACC volume and the magnitud...

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Bibliographic Details
Published in:Journal of rehabilitation research and development 2008-01, Vol.45 (3), p.451-464
Main Authors: Woodward, Steven H, Kaloupek, Danny G, Schaer, Marie, Martinez, Christelle, Eliez, Stephan
Format: Article
Language:English
Subjects:
Amygdala - anatomy & histology
Arrhythmia
Arrhythmia, Sinus - physiopathology
Autonomic Nervous System - physiopathology
Brain
Cardiovascular system
Care and treatment
Demographic aspects
Development and progression
Gulf War
Gyrus Cinguli - anatomy & histology
Gyrus Cinguli - physiopathology
Health aspects
Heart rate
Humans
Magnetic Resonance Imaging
Male
Medical imaging
Medical research
Middle Aged
Nervous system
Nervous system, Autonomic
Older people
Patient outcomes
Physiological aspects
Post-traumatic stress disorder
Psychometrics
Sinuses
Studies
Veterans
Vietnam Conflict
Warfare
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Description
Summary:Existing data suggest anterior cingulate cortex (ACC) plays a role in autonomic regulation. In persons with posttraumatic stress disorder (PTSD), autonomic regulation appears impaired and smaller mean ACC volume has been reported. This study examined relationships between ACC volume and the magnitude of respiratory sinus arrhythmia (RSA) in 77 U.S. combat veterans at rest, 40 of whom met criteria for PTSD. RSA magnitude did not differ in combat survivors with and without PTSD, which contradicts studies comparing civilians with PTSD to nontraumatized controls. RSA magnitude was positively correlated with right but not left hemisphere ACC volume. This finding was statistically independent of the presence or absence of PTSD.
ISSN:0748-7711
1938-1352
DOI:10.1682/JRRD.2007.06.0082