Regional Cerebral Blood Flow Measurement Using Tc-99m HMPAO SPECT in a Patient With Adrenoleukodystrophy

Regional cerebral blood flow (rCBF) measurement using Tc-99m HMPAO angiography and SPECT was performed in a patient with adrenoleukodystrophy. The whole brain CBF showed great reduction to 31 ml/100 g/min as compared with an age-matched normal value of 45.9 ml/100 g/min. rCBF showed extremely decrea...

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Bibliographic Details
Published in:Clinical nuclear medicine 1995-01, Vol.20 (1), p.52-54
Main Authors: MATSUDA, HIROSHI, UESUGI, HIDEJI, KAMATA, KAZUHIKO, SUNOHARA, NOBUHIKO, YAGISHITA, AKIRA
Format: Article
Language:English
Subjects:
Adrenoleukodystrophy - diagnostic imaging
Adult
Biological and medical sciences
Brain - blood supply
Brain - diagnostic imaging
Cardiovascular system
Humans
Investigative techniques, diagnostic techniques (general aspects)
Male
Medical sciences
Organotechnetium Compounds
Oximes
Radionuclide Angiography
Radionuclide investigations
Regional Blood Flow
Technetium Tc 99m Exametazime
Tomography, Emission-Computed, Single-Photon
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Summary:Regional cerebral blood flow (rCBF) measurement using Tc-99m HMPAO angiography and SPECT was performed in a patient with adrenoleukodystrophy. The whole brain CBF showed great reduction to 31 ml/100 g/min as compared with an age-matched normal value of 45.9 ml/100 g/min. rCBF showed extremely decreased values of approximately 28 and 10 ml/100 g/min in bilateral frontal cortex and white matter respectively. The SPECT scan provided useful information on gray matter involvement to MRI findings of widespread white matter lesions. This quantitative nuclear medicine technique may contribute to pathophysiologic evaluation of adrenoleukodystrophy complementary with MRI.
ISSN:0363-9762
1536-0229
DOI:10.1097/00003072-199501000-00013