Diterpenoids from the Roots of Suregada glomerulata

• Published in: Journal of natural products (Washington, D.C.) D.C.), 2008-02, Vol.71 (2), p.195-198
• Main Authors: Yan, Ren-Yi, Tan, Yong-Xia, Cui, Xi-Qiang, Chen, Ruo-Yun, Yu, De-Quan
• Format: Article
• Language: English
• Subjects: anticarcinogenic activity; Antineoplastic Agents, Phytogenic - chemistry; Antineoplastic Agents, Phytogenic - isolation & purification; Antineoplastic Agents, Phytogenic - pharmacology; Biological and medical sciences; chemical structure; Crystallography, X-Ray; cultured cells; cytotoxicity; Diterpenes - chemistry; Diterpenes - isolation & purification; Diterpenes - pharmacology; diterpenoids; Drug Screening Assays, Antitumor; Drugs, Chinese Herbal - chemistry; Drugs, Chinese Herbal - isolation & purification; Drugs, Chinese Herbal - pharmacology; Euphorbiaceae; General pharmacology; Humans; Medical sciences; Molecular Conformation; Molecular Structure; Pharmacognosy. Homeopathy. Health food; Pharmacology. Drug treatments; Plant Roots - chemistry; Plants, Medicinal - chemistry; roots; spectral analysis; stereochemistry; Suregada - chemistry; Suregada glomerulata
• ISSN: 0163-3864; 1520-6025
• DOI: 10.1021/np0705211

Six new diterpenoids, 7β,8α-dihydroxy-12-oxo-ent-abietan-16,14-olide (1), 3,4,18β-cyclopropa-7β,17-dihydroxy-ent-abieta-8(14),13(15)-dien-16,12-olide (2), 3α,7β-dihydroxy-ent-abieta-8(14),13(15)-dien-16,12-olide (3), 3-oxo-8β,14β-epoxy-ent-abieta-11,13(15)-dien-16,12-olide (4), 17-hydroxy-ent-pimara-8(14),15-dien-3-one (5), and 3α,6β-dihydroxy-ent-kaur-16-ene (6), and two known compounds, 7β-hydroxy-ent-abieta-8(14),13(15)-dien-16,12-olide (7) and jolkinolide B, were isolated from roots of Suregada glomerulata. The structures of the new compounds were elucidated on the basis of 1D and 2D NMR and other spectroscopic studies. The structure of compound 1 was confirmed by X-ray crystallography. Cytotoxic activities were evaluated against five human tumor cell lines.