The Radiation Chemistry of d(CpGpTpA) in the Presence of Oxygen

This report extends our investigation of double base lesions produced by irradiation of DNA model compounds. Studies of d(CpGpTpA) X-irradiated in oxygenated aqueous solution show that two of the five principal products are oligomers having adjacent bases damaged. In these oligomers guanine is hydro...

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Bibliographic Details
Published in:Radiation research 1995-04, Vol.142 (1), p.107-109
Main Authors: Budzinski, Edwin E., Dawidzik, Jean D., Wallace, John C., Freund, Harold G., Box, Harold C.
Format: Article
Language:English
Subjects:
Aqueous solutions
Biological and medical sciences
DNA
DNA Damage
Flood damage
Free radicals
Fundamental and applied biological sciences. Psychology
Lesions
Molecular biophysics
Molecules
Oligodeoxyribonucleotides - radiation effects
Oxygen
Oxygen - pharmacology
Radiation chemistry
Radiation damage
Radiation-biomolecule interaction
Radiochemistry
Short Communication
Solutes
Space life sciences
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Summary:This report extends our investigation of double base lesions produced by irradiation of DNA model compounds. Studies of d(CpGpTpA) X-irradiated in oxygenated aqueous solution show that two of the five principal products are oligomers having adjacent bases damaged. In these oligomers guanine is hydroxylated at the 8-position and an adjacent pyrimidine is degraded to a formamido remnant.
ISSN:0033-7587
1938-5404
DOI:10.2307/3578973