Quantitative EEG analysis of a single dose of psychotropic drugs in healthy probands

In a series of 74 experiments in a double blind study, 25 healthy test persons were medicated with a single dose of Clomipramin, Desipramin, Imipramin, Diazepam, Carbamazepin, Haloperidol, and a placebo. At the end of one hour, and again at the end of three hours, an EEG was made whose frequency ana...

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Bibliographic Details
Published in:Psychiatrie, Neurologie, und medizinische Psychologie Neurologie, und medizinische Psychologie, 1986-08, Vol.38 (8), p.450-455
Main Authors: Fischer, W, Streubel, F R, Heydenreich, F, Rabending, G
Format: Article
Language:ger
Subjects:
Adult
Arousal - drug effects
Brain - drug effects
Carbamazepine - pharmacology
Clomipramine - pharmacology
Desipramine - pharmacology
Diazepam - pharmacology
Electroencephalography
Evoked Potentials - drug effects
Female
Haloperidol - pharmacology
Humans
Imipramine - pharmacology
Male
Psychotropic Drugs - pharmacology
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Summary:In a series of 74 experiments in a double blind study, 25 healthy test persons were medicated with a single dose of Clomipramin, Desipramin, Imipramin, Diazepam, Carbamazepin, Haloperidol, and a placebo. At the end of one hour, and again at the end of three hours, an EEG was made whose frequency analysis revealed significant changes in about half the test persons. The antidepressives induced an increase in the theta waves, the slow alpha waves, and the slow beta waves, and a decrease in the fast alpha waves. The factors influencing the EEG are discussed.
ISSN:0033-2739