Gastric emptying in Mexican Americans compared to non-Hispanic whites

Mexican Americans, a group at high risk for type II diabetes mellitus, have higher postprandial insulin and glucose levels when compared to non-Hispanic whites. A rapid rate of gastric emptying contributes to an increased rate of nutrient absorption and subsequent greater elevation of postprandial g...

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Bibliographic Details
Published in:Digestive diseases and sciences 1995-03, Vol.40 (3), p.624-630
Main Authors: SCHWARTZ, J. G, MCMAHAN, C. A, GREEN, G. M, PHILLIPS, W. T
Format: Article
Language:English
Subjects:
Biological and medical sciences
Blood Glucose - analysis
Diabetes Mellitus, Type 2 - ethnology
Diabetes. Impaired glucose tolerance
Endocrine pancreas. Apud cells (diseases)
Endocrinopathies
Etiopathogenesis. Screening. Investigations. Target tissue resistance
European Continental Ancestry Group
Female
Gastric Emptying - physiology
Gastric Inhibitory Polypeptide - blood
Glucose
Humans
Hyperinsulinism - ethnology
Incidence
Insulin - blood
Male
Medical sciences
Mexican Americans
Mexico - ethnology
Obesity - ethnology
Risk Factors
Technetium Tc 99m Sulfur Colloid
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Summary:Mexican Americans, a group at high risk for type II diabetes mellitus, have higher postprandial insulin and glucose levels when compared to non-Hispanic whites. A rapid rate of gastric emptying contributes to an increased rate of nutrient absorption and subsequent greater elevation of postprandial glucose and insulin levels. A more rapid rate of gastric emptying and hyperinsulinemia have been observed in patients with recently diagnosed type II diabetes mellitus. In this study, we examined whether Mexican Americans have a more rapid rate of gastric emptying than non-Hispanic whites. Gastric emptying studies were performed on 32 nondiabetic Mexican Americans and on 31 nondiabetic non-Hispanic whites. The rate of gastric emptying following a liquid glucose meal was measured. Serum insulin, plasma glucose, and GIP levels were measured in fasting and postprandial blood samples collected at 15-min intervals for 2 hr. Adjusting for age, body mass index, and gender, the gastric half-emptying time of a glucose meal was significantly (P < 0.05) more rapid for the Mexican American subjects (56.5 +/- 3.4 min) compared to the non-Hispanic white subjects (66.4 +/- 3.5 min). Nondiabetic Mexican Americans empty a liquid glucose meal more rapidly from their stomachs than nondiabetic non-Hispanic whites. Rapid gastric emptying is associated with hyperinsulinemia as a normal physiologic response to increased nutrient availability. The rapid gastric emptying observed in nondiabetic Mexican Americans is associated with hyperinsulinemia and could be a contributing factor for the increased risk of obesity and type II diabetes in this population.
ISSN:0163-2116
1573-2568
DOI:10.1007/BF02064382