T Cell Receptor-MHC Class I Peptide Interactions: Affinity, Kinetics, and Specificity

A research project on the dynamics of major histocompatibility complex-peptide binding reactions used a single-site Langmuir reaction model, a two-site model and a model of a single ligand with two states. Results are discussed.

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Bibliographic Details
Published in:Science (American Association for the Advancement of Science) 1995-04, Vol.268 (5207), p.115-117
Main Authors: Fisher, Robert J., Fivash, Matthew, Corr, Maripat, Slanetz, Alfred E., Boyd, Lisa F., Jelonek, Marie T., Khilko, Sergei, Al-Ramaadi, Basel K., Kim, Young Sang, Maher, Stephen E., Alfred L. M. Bothwell, Margulies, David H.
Format: Article
Language:English
Subjects:
Antigen receptors, T cell
Biological and medical sciences
Drug interactions
Fundamental and applied biological sciences. Psychology
Fundamental immunology
Histocompatibility Antigens Class I - immunology
Immunobiology
Kinetics
Ligand binding (Biochemistry)
Ligands
Lymphoid cells: ontogeny, maturation, markers, receptors, circulation and recirculation
Major histocompatibility complex
Material transport processes
Mathematical models
Modeling
Models, Immunological
Parametric models
Physiological aspects
Protein Binding - immunology
Receptors
Receptors, Antigen, T-Cell - immunology
Simulations
T cell antigen receptors
T cells
T lymphocytes
Technical Comments
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Description
Summary:A research project on the dynamics of major histocompatibility complex-peptide binding reactions used a single-site Langmuir reaction model, a two-site model and a model of a single ligand with two states. Results are discussed.
ISSN:0036-8075
1095-9203
DOI:10.1126/science.7701331