A morbillivirus that caused fatal disease in horses and humans

A morbillivirus has been isolated and added to an increasing list of emerging viral diseases. This virus caused an outbreak of fatal respiratory disease in horses and in humans. Genetic analyses show it to be only distantly related to the classic morbilli-viruses rinderpest, measles, and canine dist...

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Bibliographic Details
Published in:Science (American Association for the Advancement of Science) 1995-04, Vol.268 (5207), p.94-97
Main Authors: Murray, K. (CSIRO Australian Animal Health Laboratory, Victoria, Australia.), Selleck, P, Hooper, P, Hyatt, A, Gould, A, Gleeson, L, Westbury, H, Hiley, L, Selvey, L, Rodwell, B
Format: Article
Language:English
Subjects:
Adult
Amino Acid Sequence
Animal viral diseases
Animals
Base Sequence
Biological and medical sciences
CABALLOS
Cell culture techniques
Cercopithecus aethiops
CHEVAL
Disease
Disease Outbreaks - veterinary
ENFERMEDADES RESPIRATORIAS
Etiology
Female
Fundamental and applied biological sciences. Psychology
GENETICA
GENETIQUE
Giant cells
Horse Diseases - epidemiology
Horse Diseases - mortality
Horse Diseases - virology
Horses
Human viral diseases
Humans
Infectious diseases
Kidney - virology
Kidneys
Lung - virology
Lungs
MALADIE RESPIRATOIRE
Male
Medical sciences
Microbiology
Middle Aged
Molecular Sequence Data
MORBILLIVIRUS
Morbillivirus - genetics
Morbillivirus - isolation & purification
Morbillivirus Infections - epidemiology
Morbillivirus Infections - mortality
Morbillivirus Infections - veterinary
Morbillivirus Infections - virology
Morphology, structure, chemical composition, physicochemical properties
Nucleocapsid
PATHOGENESE
PATOGENESIS
Pregnancy
Queensland - epidemiology
Respiratory Tract Infections - veterinary
Respiratory Tract Infections - virology
SECUENCIA NUCLEICA
SEQUENCE NUCLEIQUE
Spleen - virology
Training devices
ULTRAESTRUCTURA
ULTRASTRUCTURE
Vero Cells
Viral diseases
Viral diseases of the respiratory system and ent viral diseases
Virology
VIROSE
VIROSIS
Virus Cultivation
Viruses
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Description
Summary:A morbillivirus has been isolated and added to an increasing list of emerging viral diseases. This virus caused an outbreak of fatal respiratory disease in horses and in humans. Genetic analyses show it to be only distantly related to the classic morbilli-viruses rinderpest, measles, and canine distemper. When seen by electron microscopy, viruses had 10- and 18-nanometer surface projections that gave them a "double-fringed" appearance. The virus induced syncytia that developed in the endothelium of blood vessels, particularly the lungs
ISSN:0036-8075
1095-9203
DOI:10.1126/science.7701348