Progressive type of focal nodular hyperplasia characterized by multiple tumors and recurrence

Focal nodular hyperplasia (FNH) is usually a stable lesion that does not enlarge when studied for long periods of time; recurrence after resection has not been reported. We present a patient with a solitary FNH lesion that enlarged, was resected, and then recurred. A second resection was performed b...

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Published in:Hepatology (Baltimore, Md.) Md.), 1995-04, Vol.21 (4), p.970-975
Main Authors: Sadowski, Daniel C., Lee, Samuel S., Wanless, Ian R., Kelly, James K., Heathcote, E. Jenny
Format: Article
Language:English
Subjects:
Adult
Biological and medical sciences
Female
Gastroenterology. Liver. Pancreas. Abdomen
Humans
Hyperplasia
Liver - pathology
Liver Neoplasms - pathology
Liver. Biliary tract. Portal circulation. Exocrine pancreas
Medical sciences
Recurrence
Tumors
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Summary:Focal nodular hyperplasia (FNH) is usually a stable lesion that does not enlarge when studied for long periods of time; recurrence after resection has not been reported. We present a patient with a solitary FNH lesion that enlarged, was resected, and then recurred. A second resection was performed because of abdominal pain and disclosed multiple lesions, two of which were acutely infarcted. Thirty‐two months later there was ultrasound evidence of further recurrence. Histology of the lesions showed the usual appearance of FNH with ducts and ductules in the central stalk regions but also some areas with minimal ductular differentiation and scanty connective tissue. Because of the clinical and histological appearance, the lesions in this patient were distinct from the usual type of FNH and merit the name “focal nodular hyperplasia, progressive type.” (HEPATOLOGY 1995; 21:970–975.)
ISSN:0270-9139
1527-3350
DOI:10.1002/hep.1840210413