Lewy Body Dementia Without Alzheimer Changes

Three patients with clinical Alzheimer's disease were found at postmortem examination to have Lewy-bodies and Lewy-like bodies in the cerebral cortex and the pigmented brainstem nuclei. Neuritic plaques were found in neocortical areas but no neurofibrillary tangles. The distribution of cortical...

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Bibliographic Details
Published in:Canadian journal of neurological sciences 1986-11, Vol.13 (S4), p.490-497
Main Authors: Sima, A.A.F., Clark, A.W., Sternberger, N.A., Sternberger, L.A.
Format: Article
Language:English
Subjects:
Aged
Brain - ultrastructure
Cellular Clues to Pathogenesis
Dementia - pathology
Female
Histocytochemistry
Humans
Immunochemistry
Inclusion Bodies - ultrastructure
Male
Microscopy, Electron
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Summary:Three patients with clinical Alzheimer's disease were found at postmortem examination to have Lewy-bodies and Lewy-like bodies in the cerebral cortex and the pigmented brainstem nuclei. Neuritic plaques were found in neocortical areas but no neurofibrillary tangles. The distribution of cortical neuronal inclusions correlated with the proposed projection of dopamine terminals. Neuronal cell loss was marked in the ventral tegmental area (paranigral nucleus) and the basal nucleus of Meynert, suggesting a defect in dopaminergic and cholinergic innervation of the cerebral cortex. Immunohistochemical investigations revealed positive staining of cortical Lewy- and Lewy-like bodies for monoclonal antibodies to phosphorylated neurofilaments (03-44, 06-17, 04-7). Also cerebral neurons containing no inclusions showed positivity, suggesting an early neurofilament abnormality, preceding the formation of Lewy-type inclusions.
ISSN:0317-1671
2057-0155
DOI:10.1017/S0317167100037185