Hypermethylation at a chromosome 17 “Hot spot” is a common event in ovarian cancer

Alterations of normal DNA methylation patterns have been reported in various types of human tumors. These alterations are represented by genome wide hypomethylation and by region specific hyper methylation. One commonly hypermethylated region is 17p13.3 (D17S5), the putative site of a tumor suppress...

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Bibliographic Details
Published in:Human pathology 1995-04, Vol.26 (4), p.398-401
Main Authors: Pieretti, Maura, Powell, Deborah E, Gallion, Holly H, Conway, Pamela S, Case, Elizabeth A, Turker, Mitchell S
Format: Article
Language:English
Subjects:
Biological and medical sciences
Calcitonin - metabolism
chromosome 17
Chromosomes, Human, Pair 17 - metabolism
Female
Female genital diseases
Gynecology. Andrology. Obstetrics
Humans
hypermethylation
Medical sciences
Methylation
Ovarian Neoplasms - metabolism
Ovarian Neoplasms - pathology
ovarian tumors
Tumors
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Summary:Alterations of normal DNA methylation patterns have been reported in various types of human tumors. These alterations are represented by genome wide hypomethylation and by region specific hyper methylation. One commonly hypermethylated region is 17p13.3 (D17S5), the putative site of a tumor suppressor gene. In this study we report that hypermethylation at this locus occurs frequently (33%) in ovarian tumors. We reported previously that loss of chromosome 17 is a common event in serous epithelial ovarian tumors. A correlation of the methylation event and chromosome 17 loss suggests that hypermethylation at D17S5 precedes chromosome 17 loss.
ISSN:0046-8177
1532-8392
DOI:10.1016/0046-8177(95)90140-X