A New Cyclic Lipopeptide Antibiotic, Enamidonin

We have been screening microbial fermentation for inhibitors of mitogenic activity of epidermal growth factor. During the screening, a new lipopeptide antibiotic, enamidonin (Fig. 1) which shows detransforming activity of a rat cell line transformed with a temperature sensitive Rous sarcoma virus (s...

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Bibliographic Details
Published in:Journal of antibiotics 1995/02/25, Vol.48(2), pp.185-187
Main Authors: KOSHINO, SATOMI, KOSHINO, HIROYUKI, MATSUURA, NOBUYASU, KOBINATA, KIMIE, ONOSE, RIE, ISONO, KIYOSHI, OSADA, HIROYUKI
Format: Article
Language:English
Subjects:
Animals
Anti-Bacterial Agents - chemistry
Anti-Bacterial Agents - isolation & purification
Anti-Bacterial Agents - pharmacology
Cell Line, Transformed
Chromatography, High Pressure Liquid
Lipopeptides
Magnetic Resonance Spectroscopy
Mass Spectrometry
Peptides
Peptides, Cyclic - chemistry
Peptides, Cyclic - isolation & purification
Peptides, Cyclic - pharmacology
Rats
Spectrophotometry, Ultraviolet
Streptomyces - chemistry
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Summary:We have been screening microbial fermentation for inhibitors of mitogenic activity of epidermal growth factor. During the screening, a new lipopeptide antibiotic, enamidonin (Fig. 1) which shows detransforming activity of a rat cell line transformed with a temperature sensitive Rous sarcoma virus (src super(ts)-NRK cells), has been isolated from a culture broth of Streptomyces sp. 91-75. The producing strain was isolated from a soil sample collected in Imaichi city, Tochigi prefecture and deposited at the National Institute of Bioscience and Human-Technology under the accession number FERM P-14190.
ISSN:0021-8820
1881-1469
DOI:10.7164/antibiotics.48.185