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Absence of Infectious Retinitis after Injection of Human Cytomegalovirus into Rabbit Eyes
The rabbit model of human cytomegalovirus (HCMV) retinitis was evaluated by preretinal and intravitreal injection of HCMV into rabbit eyes. Ocular disease was evaluated by indirect ophthalmoscopy, histopathology, and immunohistochemistry. Vitritis, optic nerve congestion, multiple small white infilt...
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| Published in: | The Journal of infectious diseases 1995-04, Vol.171 (4), p.782-787 |
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| Main Authors: | , , , , , , , , , , , , , |
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| Language: | English |
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| container_end_page | 787 |
| container_issue | 4 |
| container_start_page | 782 |
| container_title | The Journal of infectious diseases |
| container_volume | 171 |
| creator | Tatebayashi, Misako Neyts, Johan Besen, Gilberto Flores-Aguilar, Marisa Smith, Irene L. Wiley, Clayton A. Spector, Stephen A. Lynn, Germaine Bergeron Maudgal, Prabhat C. Clercq, Erik De Gangan, Pacifico A. Chavez, Eugenio Russack, Valentina Freeman, William R. |
| description | The rabbit model of human cytomegalovirus (HCMV) retinitis was evaluated by preretinal and intravitreal injection of HCMV into rabbit eyes. Ocular disease was evaluated by indirect ophthalmoscopy, histopathology, and immunohistochemistry. Vitritis, optic nerve congestion, multiple small white infiltrates in the cortical vitreous or on the retinal surface, and retinal detachments were seen. Histopathologic examination showed inflammatory cell infiltration in the preretinal vitreous, optic nerve, and transiently in the superficial inner retina. Retinal structure was preserved except for changes in areas of retinal detachment. No necrosis or destruction of the retina was seen. Immunohistochemistry showed no evidence of cytomegalovirus infection. Inoculation of culture medium containing fetal calf serum caused a similar reaction. It is concluded that vitreous and retinal inoculation of HCMV in the rabbit eye caused nonspecific inflammation without evidence of infection, so this is not a suitable model for HCMV retinitis. |
| doi_str_mv | 10.1093/infdis/171.4.782 |
| format | article |
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Ocular disease was evaluated by indirect ophthalmoscopy, histopathology, and immunohistochemistry. Vitritis, optic nerve congestion, multiple small white infiltrates in the cortical vitreous or on the retinal surface, and retinal detachments were seen. Histopathologic examination showed inflammatory cell infiltration in the preretinal vitreous, optic nerve, and transiently in the superficial inner retina. Retinal structure was preserved except for changes in areas of retinal detachment. No necrosis or destruction of the retina was seen. Immunohistochemistry showed no evidence of cytomegalovirus infection. Inoculation of culture medium containing fetal calf serum caused a similar reaction. It is concluded that vitreous and retinal inoculation of HCMV in the rabbit eye caused nonspecific inflammation without evidence of infection, so this is not a suitable model for HCMV retinitis.</description><identifier>ISSN: 0022-1899</identifier><identifier>EISSN: 1537-6613</identifier><identifier>DOI: 10.1093/infdis/171.4.782</identifier><identifier>PMID: 7706803</identifier><language>eng</language><publisher>United States: The University of Chicago Press</publisher><subject>Animals ; Antigens, Viral - analysis ; Culture Media ; Cytomegalovirus ; Cytomegalovirus - immunology ; Cytomegalovirus - pathogenicity ; Cytomegalovirus infections ; Cytomegalovirus Retinitis - pathology ; Cytomegalovirus Retinitis - virology ; Disease Models, Animal ; Eyes ; Humans ; Infections ; Inoculation ; Major Articles ; Optic nerve ; Rabbits ; Retina ; Retina - pathology ; Retina - virology ; Retinitis ; Viruses</subject><ispartof>The Journal of infectious diseases, 1995-04, Vol.171 (4), p.782-787</ispartof><rights>Copyright 1995 The University of Chicago</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c385t-d30b5eea41f34c91de1e9f7d50b6a58f8faa9e4d0e5b604a49f6e5eb989386ec3</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.jstor.org/stable/pdf/30132162$$EPDF$$P50$$Gjstor$$H</linktopdf><linktohtml>$$Uhttps://www.jstor.org/stable/30132162$$EHTML$$P50$$Gjstor$$H</linktohtml><link.rule.ids>314,780,784,27924,27925,58238,58471</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/7706803$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Tatebayashi, Misako</creatorcontrib><creatorcontrib>Neyts, Johan</creatorcontrib><creatorcontrib>Besen, Gilberto</creatorcontrib><creatorcontrib>Flores-Aguilar, Marisa</creatorcontrib><creatorcontrib>Smith, Irene L.</creatorcontrib><creatorcontrib>Wiley, Clayton A.</creatorcontrib><creatorcontrib>Spector, Stephen A.</creatorcontrib><creatorcontrib>Lynn, Germaine Bergeron</creatorcontrib><creatorcontrib>Maudgal, Prabhat C.</creatorcontrib><creatorcontrib>Clercq, Erik De</creatorcontrib><creatorcontrib>Gangan, Pacifico A.</creatorcontrib><creatorcontrib>Chavez, Eugenio</creatorcontrib><creatorcontrib>Russack, Valentina</creatorcontrib><creatorcontrib>Freeman, William R.</creatorcontrib><title>Absence of Infectious Retinitis after Injection of Human Cytomegalovirus into Rabbit Eyes</title><title>The Journal of infectious diseases</title><addtitle>J Infect Dis</addtitle><description>The rabbit model of human cytomegalovirus (HCMV) retinitis was evaluated by preretinal and intravitreal injection of HCMV into rabbit eyes. Ocular disease was evaluated by indirect ophthalmoscopy, histopathology, and immunohistochemistry. Vitritis, optic nerve congestion, multiple small white infiltrates in the cortical vitreous or on the retinal surface, and retinal detachments were seen. Histopathologic examination showed inflammatory cell infiltration in the preretinal vitreous, optic nerve, and transiently in the superficial inner retina. Retinal structure was preserved except for changes in areas of retinal detachment. No necrosis or destruction of the retina was seen. Immunohistochemistry showed no evidence of cytomegalovirus infection. Inoculation of culture medium containing fetal calf serum caused a similar reaction. It is concluded that vitreous and retinal inoculation of HCMV in the rabbit eye caused nonspecific inflammation without evidence of infection, so this is not a suitable model for HCMV retinitis.</description><subject>Animals</subject><subject>Antigens, Viral - analysis</subject><subject>Culture Media</subject><subject>Cytomegalovirus</subject><subject>Cytomegalovirus - immunology</subject><subject>Cytomegalovirus - pathogenicity</subject><subject>Cytomegalovirus infections</subject><subject>Cytomegalovirus Retinitis - pathology</subject><subject>Cytomegalovirus Retinitis - virology</subject><subject>Disease Models, Animal</subject><subject>Eyes</subject><subject>Humans</subject><subject>Infections</subject><subject>Inoculation</subject><subject>Major Articles</subject><subject>Optic nerve</subject><subject>Rabbits</subject><subject>Retina</subject><subject>Retina - pathology</subject><subject>Retina - virology</subject><subject>Retinitis</subject><subject>Viruses</subject><issn>0022-1899</issn><issn>1537-6613</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1995</creationdate><recordtype>article</recordtype><recordid>eNqFkE1LI0EURQtx0Iy6dzPQK3cdX3V9LyWoEQQZcWB0U1R3v5LKpLu1qiLm30_HhMxyVm9x7r3wDiHnFKYUDLsMvW9DuqSKTvlU6eqATKhgqpSSskMyAaiqkmpjjsn3lBYAwJlUR-RIKZAa2IQ8X9UJ-waLwRd3vccmh2GVikfMoQ85pML5jHFEiy_Ub3LzVef6YrbOQ4evbjl8hDhWQp-H4tHVdcjF9RrTKfnm3TLh2e6ekF8310-zeXn_cHs3u7ovG6ZFLlsGtUB0nHrGG0NbpGi8agXU0gnttXfOIG8BRS2BO268RIG10YZpiQ07IRfb3bc4vK8wZduF1OBy6XocX7FKVSC4EP8NUqmNqCo5BmEbbOKQUkRv32LoXFxbCnaj3W6121G75XbUPlZ-7LZXdYftvrDz_I8vUh7iHjOgrKJy0y-3PKSMn3vu4h8rFVPCzn-_WPnz9km9GGGB_QW5pJk_</recordid><startdate>19950401</startdate><enddate>19950401</enddate><creator>Tatebayashi, Misako</creator><creator>Neyts, Johan</creator><creator>Besen, Gilberto</creator><creator>Flores-Aguilar, Marisa</creator><creator>Smith, Irene L.</creator><creator>Wiley, Clayton A.</creator><creator>Spector, Stephen A.</creator><creator>Lynn, Germaine Bergeron</creator><creator>Maudgal, Prabhat C.</creator><creator>Clercq, Erik De</creator><creator>Gangan, Pacifico A.</creator><creator>Chavez, Eugenio</creator><creator>Russack, Valentina</creator><creator>Freeman, William R.</creator><general>The University of Chicago Press</general><general>University of Chicago Press</general><scope>BSCLL</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7U9</scope><scope>H94</scope><scope>7X8</scope></search><sort><creationdate>19950401</creationdate><title>Absence of Infectious Retinitis after Injection of Human Cytomegalovirus into Rabbit Eyes</title><author>Tatebayashi, Misako ; Neyts, Johan ; Besen, Gilberto ; Flores-Aguilar, Marisa ; Smith, Irene L. ; Wiley, Clayton A. ; Spector, Stephen A. ; Lynn, Germaine Bergeron ; Maudgal, Prabhat C. ; Clercq, Erik De ; Gangan, Pacifico A. ; Chavez, Eugenio ; Russack, Valentina ; Freeman, William R.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c385t-d30b5eea41f34c91de1e9f7d50b6a58f8faa9e4d0e5b604a49f6e5eb989386ec3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1995</creationdate><topic>Animals</topic><topic>Antigens, Viral - analysis</topic><topic>Culture Media</topic><topic>Cytomegalovirus</topic><topic>Cytomegalovirus - immunology</topic><topic>Cytomegalovirus - pathogenicity</topic><topic>Cytomegalovirus infections</topic><topic>Cytomegalovirus Retinitis - pathology</topic><topic>Cytomegalovirus Retinitis - virology</topic><topic>Disease Models, Animal</topic><topic>Eyes</topic><topic>Humans</topic><topic>Infections</topic><topic>Inoculation</topic><topic>Major Articles</topic><topic>Optic nerve</topic><topic>Rabbits</topic><topic>Retina</topic><topic>Retina - pathology</topic><topic>Retina - virology</topic><topic>Retinitis</topic><topic>Viruses</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Tatebayashi, Misako</creatorcontrib><creatorcontrib>Neyts, Johan</creatorcontrib><creatorcontrib>Besen, Gilberto</creatorcontrib><creatorcontrib>Flores-Aguilar, Marisa</creatorcontrib><creatorcontrib>Smith, Irene L.</creatorcontrib><creatorcontrib>Wiley, Clayton A.</creatorcontrib><creatorcontrib>Spector, Stephen A.</creatorcontrib><creatorcontrib>Lynn, Germaine Bergeron</creatorcontrib><creatorcontrib>Maudgal, Prabhat C.</creatorcontrib><creatorcontrib>Clercq, Erik De</creatorcontrib><creatorcontrib>Gangan, Pacifico A.</creatorcontrib><creatorcontrib>Chavez, Eugenio</creatorcontrib><creatorcontrib>Russack, Valentina</creatorcontrib><creatorcontrib>Freeman, William R.</creatorcontrib><collection>Istex</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Virology and AIDS Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>The Journal of infectious diseases</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Tatebayashi, Misako</au><au>Neyts, Johan</au><au>Besen, Gilberto</au><au>Flores-Aguilar, Marisa</au><au>Smith, Irene L.</au><au>Wiley, Clayton A.</au><au>Spector, Stephen A.</au><au>Lynn, Germaine Bergeron</au><au>Maudgal, Prabhat C.</au><au>Clercq, Erik De</au><au>Gangan, Pacifico A.</au><au>Chavez, Eugenio</au><au>Russack, Valentina</au><au>Freeman, William R.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Absence of Infectious Retinitis after Injection of Human Cytomegalovirus into Rabbit Eyes</atitle><jtitle>The Journal of infectious diseases</jtitle><addtitle>J Infect Dis</addtitle><date>1995-04-01</date><risdate>1995</risdate><volume>171</volume><issue>4</issue><spage>782</spage><epage>787</epage><pages>782-787</pages><issn>0022-1899</issn><eissn>1537-6613</eissn><abstract>The rabbit model of human cytomegalovirus (HCMV) retinitis was evaluated by preretinal and intravitreal injection of HCMV into rabbit eyes. Ocular disease was evaluated by indirect ophthalmoscopy, histopathology, and immunohistochemistry. Vitritis, optic nerve congestion, multiple small white infiltrates in the cortical vitreous or on the retinal surface, and retinal detachments were seen. Histopathologic examination showed inflammatory cell infiltration in the preretinal vitreous, optic nerve, and transiently in the superficial inner retina. Retinal structure was preserved except for changes in areas of retinal detachment. No necrosis or destruction of the retina was seen. Immunohistochemistry showed no evidence of cytomegalovirus infection. Inoculation of culture medium containing fetal calf serum caused a similar reaction. It is concluded that vitreous and retinal inoculation of HCMV in the rabbit eye caused nonspecific inflammation without evidence of infection, so this is not a suitable model for HCMV retinitis.</abstract><cop>United States</cop><pub>The University of Chicago Press</pub><pmid>7706803</pmid><doi>10.1093/infdis/171.4.782</doi><tpages>6</tpages></addata></record> |
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| identifier | ISSN: 0022-1899 |
| ispartof | The Journal of infectious diseases, 1995-04, Vol.171 (4), p.782-787 |
| issn | 0022-1899 1537-6613 |
| language | eng |
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| source | JSTOR Archival Journals and Primary Sources Collection; Oxford University Press:Jisc Collections:Oxford Journal Archive: Access period 2024-2025 |
| subjects | Animals Antigens, Viral - analysis Culture Media Cytomegalovirus Cytomegalovirus - immunology Cytomegalovirus - pathogenicity Cytomegalovirus infections Cytomegalovirus Retinitis - pathology Cytomegalovirus Retinitis - virology Disease Models, Animal Eyes Humans Infections Inoculation Major Articles Optic nerve Rabbits Retina Retina - pathology Retina - virology Retinitis Viruses |
| title | Absence of Infectious Retinitis after Injection of Human Cytomegalovirus into Rabbit Eyes |
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