A preliminary study on plasma concentrations of bifemelane, indeloxazine and propentofylline in aged patients with organic brain disorders

1. 1. Plasma concentrations of cerebral metabolic activating drugs (bifemelane, indeloxazine and propentofylline) were studied in 68 patients (male 25, female 43) with dementia or other organic brain diseases. 2. 2. The variations in plasma concentrations of these drugs were much bigger than expecte...

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Bibliographic Details
Published in:Progress in neuro-psychopharmacology & biological psychiatry 1995, Vol.19 (1), p.59-64
Main Authors: Minami, Masayuki, Arai, Heii, Takahashi, Tadashi, Kimura, Michihiro, Noguchi, Iwahide, Suzuki, Takeo, Inoue, Reiichi
Format: Article
Language:English
Subjects:
Aged
Antidepressive Agents - therapeutic use
Benzhydryl Compounds - blood
Benzhydryl Compounds - metabolism
bifemelane
cerebral metabolic activating agents
dementia
Dementia - blood
Dementia - drug therapy
Female
Humans
indeloxazine
Male
Morpholines - blood
organic brain disease
plasma concentration
propentofylline
Xanthines - blood
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Summary:1. 1. Plasma concentrations of cerebral metabolic activating drugs (bifemelane, indeloxazine and propentofylline) were studied in 68 patients (male 25, female 43) with dementia or other organic brain diseases. 2. 2. The variations in plasma concentrations of these drugs were much bigger than expected. Measurements of bifemelane level with time course also disclosed that the concentrations were relatively stable for several months, but they varied very much among patients. 3. 3. These findings suggest that drug monitoring are important in terms of evaluation of drug efficacy and prevention of side effects.
ISSN:0278-5846
1878-4216
DOI:10.1016/0278-5846(94)00104-P