Correlation between left frontal phospholipids and Wisconsin card sort test performance in schizophrenia

The relationship between frontal lobe phospholipid measures as measured by in vivo 31phosphorus magnetic resonance spectroscopic imaging and performance on the Wisconsin Card Sort Test was examined in 16 chronic schizophrenic patients and I3 normal controls. Lower left frontal phosphomonoester level...

Full description

Saved in:
Bibliographic Details
Published in:Schizophrenia research 1995, Vol.14 (2), p.177-181
Main Authors: Deicken, Raymond F., Merrin, Edward L., Floyd, Thomas C., Weiner, Michael W.
Format: Article
Language:English
Subjects:
Adult
Adult and adolescent clinical studies
Biological and medical sciences
Corpus Callosum - pathology
Dominance, Cerebral - physiology
Frontal lobe
Frontal Lobe - pathology
Humans
Magnetic Resonance Imaging
Magnetic resonance spectroscopy
Male
Medical sciences
Middle Aged
Neuropsychological Tests
Phospholipid
Phospholipids - metabolism
Psychology. Psychoanalysis. Psychiatry
Psychopathology. Psychiatry
Psychoses
Schizophrenia
Schizophrenia - diagnosis
Schizophrenia - physiopathology
Schizophrenic Psychology
Wechsler Scales
Citations: Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:The relationship between frontal lobe phospholipid measures as measured by in vivo 31phosphorus magnetic resonance spectroscopic imaging and performance on the Wisconsin Card Sort Test was examined in 16 chronic schizophrenic patients and I3 normal controls. Lower left frontal phosphomonoester levels in the schizophrenics were associated with fewer categories achieved, lower percent conceptual level, and greater total errors. No significant correlations between frontal phospholipid measures and performance on the WCST were noted in the controls. The results suggest a relationship between altered left frontal phospholipid metabolism and a specific measure of frontal lobe neuropsychological functioning.
ISSN:0920-9964
1573-2509
DOI:10.1016/0920-9964(94)00036-8