AZINOMYCINS A AND B, NEW ANTITUMOR ANTIBIOTICS: I. PRODUCING ORGANISM, FERMENTATION, ISOLATION, AND CHARACTERIZATION

A strain of Streptomyces griseofuscus S42227 (FERM P-8443) was found to produce new antitumor antibiotics, called azinomycins A and B. The molecular formulas of azinomycins A and B were determined as C30H33N3O10 and C31H33N3O11, respectively. They were active against Gram-positive bacteria, Gram-neg...

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Bibliographic Details
Published in:Journal of antibiotics 1986, Vol.39(11), pp.1527-1532
Main Authors: NAGAOKA, KATSUHIKO, MATSUMOTO, MASARU, OONO, JUNJI, YOKOI, KOUICHI, ISHIZEKI, SEIJI, NAKASHIMA, TOSHIAKI
Format: Article
Language:English
Subjects:
Animals
Anti-Bacterial Agents
Antibiotics, Antineoplastic - biosynthesis
Antibiotics, Antineoplastic - isolation & purification
Antibiotics, Antineoplastic - pharmacology
Antiviral drugs
Biological and medical sciences
Biotechnology
Chemical Phenomena
Chemistry
Fermentation
Fundamental and applied biological sciences. Psychology
General pharmacology
Glycopeptides - biosynthesis
Glycopeptides - isolation & purification
Glycopeptides - pharmacology
Gram-Negative Bacteria - drug effects
Gram-Positive Bacteria - drug effects
Health. Pharmaceutical industry
Industrial applications and implications. Economical aspects
Leukemia L5178 - drug therapy
Medical sciences
Microbial Sensitivity Tests
Naphthalenes
Peptides
Pharmacology. Drug treatments
Physicochemical properties. Structure-activity relationships
Production of active biomolecules
Spectrophotometry, Infrared
Streptomyces - metabolism
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Summary:A strain of Streptomyces griseofuscus S42227 (FERM P-8443) was found to produce new antitumor antibiotics, called azinomycins A and B. The molecular formulas of azinomycins A and B were determined as C30H33N3O10 and C31H33N3O11, respectively. They were active against Gram-positive bacteria, Gram-negative bacteria and L5178Y cells in tissue culture.
ISSN:0021-8820
1881-1469
DOI:10.7164/antibiotics.39.1527