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Glycogen synthase kinase-3 and dorsoventral patterning in Xenopus embryos

Glycogen synthase kinase 3 (GSK-3) is homologous to the product of the Drosophila gene shaggy (zeste-white 3) , which is required for signalling by wingless during Drosophila development. To test whether GSK-3 is also involved in vertebrate pattern formation, its role was investigated during early X...

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Bibliographic Details
Published in:Nature (London) 1995-04, Vol.374 (6523), p.617-622
Main Authors: He, Xi, Saint-Jeannet, Jean-Pierre, Woodgett, James R, Varmus, Harold E, Dawid, Igor B
Format: Article
Language:English
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Summary:Glycogen synthase kinase 3 (GSK-3) is homologous to the product of the Drosophila gene shaggy (zeste-white 3) , which is required for signalling by wingless during Drosophila development. To test whether GSK-3 is also involved in vertebrate pattern formation, its role was investigated during early Xenopus development. It was found that dominant-negative GSK-3 mutants induced dorsal differentiation, whereas wild-type GSK-3 induced ventralization. These results indicate that GSK-3 is required for ventral differentiation, and suggest that dorsal differentiation may involve the suppression of GSK-3 activity by a wingless /wnt-related signal.
ISSN:0028-0836
1476-4687
DOI:10.1038/374617a0