Cerebrospinal fluid HVA, central brain atrophy, and clinical state in schizophrenia

In 16 patients with chronic schizophrenia, cerebrospinal fluid (CSF) concentrations of homovanillic acid (HVA) showed a significant negative correlation with computed tomographic measures of brain third ventricle size. Clinical state during a drug-free period was also significantly correlated with C...

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Bibliographic Details
Published in:Psychiatry research 1986-11, Vol.19 (3), p.207-214
Main Authors: Houston, John P., Maas, James W., Bowden, Charles L., Contreras, Salvador A., McIntyre, Kathryn L., Javors, Martin A.
Format: Article
Language:English
Subjects:
Adult
Atrophy
Biological and medical sciences
Brain - pathology
brain atrophy
Cerebral Ventricles - pathology
Chronic Disease
computed tomography
Female
homovanillic acid
Homovanillic Acid - cerebrospinal fluid
Humans
Male
Medical sciences
Middle Aged
Miscellaneous
Psychology. Psychoanalysis. Psychiatry
Psychopathology. Psychiatry
Schizophrenia
Schizophrenia - cerebrospinal fluid
Schizophrenia - pathology
Techniques and methods
Tomography, X-Ray Computed
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Summary:In 16 patients with chronic schizophrenia, cerebrospinal fluid (CSF) concentrations of homovanillic acid (HVA) showed a significant negative correlation with computed tomographic measures of brain third ventricle size. Clinical state during a drug-free period was also significantly correlated with CSF HVA level, but not with third ventricle size when the effect of CSF HVA was partialed out. The authors propose that these findings may reflect an atrophic process involving structures around the third ventricle and a decrease in dopaminergic activity.
ISSN:0165-1781
1872-7123
DOI:10.1016/0165-1781(86)90099-5