Current theories of pathogenesis and treatment of nonocclusive mesenteric ischemia

Nonocclusive mesenteric ischemia (NOMI) is a poorly understood condition marked by progressive intestinal ischemia leading to infarction, sepsis, and death in a high proportion of patients. The mortality rate for this intestinal disorder remains high, even when the diagnosis is made early in the dis...

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Bibliographic Details
Published in:Digestive diseases and sciences 1995-04, Vol.40 (4), p.709-716
Main Authors: WILCOX, M. G, HOWARD, T. J, PLASKON, L. A, UNTHANK, J. L, MADURA, J. A
Format: Article
Language:English
Subjects:
Animals
Biological and medical sciences
Enteral Nutrition - adverse effects
Gastroenterology. Liver. Pancreas. Abdomen
Humans
Infections - complications
Intestinal Mucosa - metabolism
Ischemia - etiology
Ischemia - physiopathology
Ischemia - therapy
Medical sciences
Mesentery - blood supply
Other diseases. Semiology
Reperfusion Injury - complications
Stomach. Duodenum. Small intestine. Colon. Rectum. Anus
Vasoconstriction
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Summary:Nonocclusive mesenteric ischemia (NOMI) is a poorly understood condition marked by progressive intestinal ischemia leading to infarction, sepsis, and death in a high proportion of patients. The mortality rate for this intestinal disorder remains high, even when the diagnosis is made early in the disease course. This paper presents a comprehensive review of NOMI with a detailed discussion of its history, pathophysiology, diagnosis, and treatment.
ISSN:0163-2116
1573-2568
DOI:10.1007/bf02064966