Difference in Mode of Action of Alpha_1 -Adrenoceptor Antagonists on Some Vascular Smooth Muscles and Efficacy

• Published in: Japanese Journal of Pharmacology 1986-10, Vol.42 (2), p.237-241
• Main Authors: Takayanagi, I, Konno, F, Toru, T, Takahashi, R
• Format: Article
• Language: English
• Subjects: Adrenergic alpha-Agonists - pharmacology; Adrenergic alpha-Antagonists - pharmacology; Animals; Aorta, Thoracic - drug effects; Femoral Vein - drug effects; In Vitro Techniques; Male; Models, Biological; Muscle, Smooth, Vascular - drug effects; Portal Vein - drug effects; Prazosin - pharmacology; Rabbits; Sulfonamides - pharmacology
• ISSN: 0021-5198
• DOI: 10.1254/jjp.42.237

Effect of YM-12617, a selective and potent alpha_1 -adrenoceptor antagonist on dose-response curves of alpha_1 -adrenoceptor agonists, norepinephrine, phenylephrine and naphazoline, was tested in isolated rabbit vascular smooth muscles such as the femoral vein, portal vein and aorta. YM-12617 shifted the dose-response curves for norepinephrine and phenylephrine to the right and also declined the maximum response in the femoral vein, where norepinephrine and phenylephrine behaved as low efficacy agonists. Similar results were obtained on the curve of naphazoline in the portal vein, where the efficacy of naphazoline was low. However, the efficacies of norepinephrine, phenylephrine and naphazoline were high in the aorta. The dose-response curves for three alpha_1 -agonists were shifted by YM-12617 in a parallel manner in the aorta. The curves of norepinephrine and phenylephrine were also shifted by YM-12617 in the portal vein, where the efficacies of both the alpha_1 -agonists were high. The present results suggest that the mode of antagonism between the alpha_1 -agonist and alpha_1 -antagonist is dependent on the efficacy of the alpha_1 -agonist which depends upon the receptor-density in the organ used.