Specific decrease of anti-pseudomonal IgA after anti-pseudomonal therapy in cystic fibrosis

In patients with cystic fibrosis (CF) and chronic colonisation with Pseudomonas aeruginosa, specific anti-pseudomonal IgG and IgA, as well as serum immunoreactive protein C, WBC and differential count, ESR, pulmonary function and chest radiograph score were determined before and after a 2 week intra...

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Bibliographic Details
Published in:European journal of pediatrics 1995-02, Vol.154 (2), p.157-160
Main Authors: DE BOECK, K, EGGERMONT, E, SMET, M, VAN REEMPTS, P, VAN BEVER, H. P, STEVENS, W. J
Format: Article
Language:English
Subjects:
Antibodies, Bacterial - analysis
Bacterial diseases
Bacterial diseases of the respiratory system
Biological and medical sciences
C-Reactive Protein - analysis
Child
Cystic Fibrosis - complications
Cystic Fibrosis - immunology
Female
Human bacterial diseases
Humans
Immunoglobulin A - analysis
Immunoglobulin G - analysis
Infectious diseases
Leukocyte Count
Lung Diseases - drug therapy
Lung Diseases - immunology
Male
Medical sciences
Pseudomonas aeruginosa - immunology
Pseudomonas Infections - drug therapy
Pseudomonas Infections - immunology
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Summary:In patients with cystic fibrosis (CF) and chronic colonisation with Pseudomonas aeruginosa, specific anti-pseudomonal IgG and IgA, as well as serum immunoreactive protein C, WBC and differential count, ESR, pulmonary function and chest radiograph score were determined before and after a 2 week intravenous course of anti-pseudomonal antibiotics in 32 cases of acute exacerbation of pulmonary infection. Specific anti-pseudomonal IgA but not specific anti-pseudomonal IgG decreased significantly after treatment. Log of anti-pseudomonal IgA but not log anti-pseudomonal IgG correlated well with disease severity as assessed by the Brasfield chest radiograph score (r 0.57), forced expiratory volume in 1 s (r 0.6) as well as C-reactive protein (r 0.62). Specific anti-pseudomonal IgA may be a better parameter than specific IgG in the follow up of lung infection in patients with CF, probably because it more closely reflects ongoing endobronchial infection, the major pathology in CF lungs.
ISSN:0340-6199
1432-1076
DOI:10.1007/BF01991922