Congenital Cytomegalovirus Infection in Offspring of Liver Transplant Recipients

There has been an increasing number of women undergoing liver transplantation during their childbearing years. As the number of pregnancies among these women increases, complications during pregnancy and risks to the fetus associated with liver transplantation will be better defined. We report three...

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Bibliographic Details
Published in:Clinical infectious diseases 1995-01, Vol.20 (1), p.52-55
Main Authors: Laifer, Steven A., Ehrlich, Garth D., Huff, Dale S., Balsan, Michael J., Scantlebury, Velma P.
Format: Article
Language:English
Subjects:
Adult
Biological and medical sciences
Blood
Clinical Articles
Cytomegalovirus
Cytomegalovirus - genetics
Cytomegalovirus - isolation & purification
Cytomegalovirus infections
Cytomegalovirus Infections - complications
Cytomegalovirus Infections - congenital
Cytomegalovirus Infections - transmission
DNA, Viral - genetics
DNA, Viral - isolation & purification
Female
Ganciclovir - therapeutic use
Gestational Age
Humans
Infant, Newborn
Infant, Premature
Infections
Liver
Liver transplantation
Liver Transplantation - adverse effects
Liver, biliary tract, pancreas, portal circulation, spleen
Medical sciences
Placenta
Polymerase Chain Reaction
Pre-Eclampsia - complications
Pregnancy
Pregnancy Complications, Infectious - drug therapy
Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases
Surgery of the digestive system
Transplantation
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Summary:There has been an increasing number of women undergoing liver transplantation during their childbearing years. As the number of pregnancies among these women increases, complications during pregnancy and risks to the fetus associated with liver transplantation will be better defined. We report three cases of cytomegalovirus (CMV) infection in offspring of liver transplant recipients. Two of these recipients had preterm labor and gave birth at ∼23 weeks' gestation; both neonates had clinical (hydrops fetalis), laboratory, and placental evidence of CMV infection. The third recipient gave birth at 26 weeks' gestation because of severe preeclampsia, and the neonate died at 12 days of age of CMV sepsis. Placental CMV infection was confirmed in this case by polymerase chain reaction analysis, which is a valuable tool for prospectively or retrospectively diagnosing this infection. Our findings indicate that CMV infection poses a significant risk to offspring of liver transplant recipients.
ISSN:1058-4838
1537-6591
DOI:10.1093/clinids/20.1.52