Predicted structure of the adenovirus DNA binding protein

The DNA sequence of a portion of the MAV1 SmaI-D fragment coding for the C-terminal 147 amino acids of the adenoviral DNA-binding protein (DBP) has been determined. A multiple sequence alignment was constructed of the MAV1 fragment and the DBPs of Ad.2, 4, 5, 7, 12, 40, and 41 to examine the degree...

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Bibliographic Details
Published in:Virus genes 1995-01, Vol.9 (2), p.171-175
Main Authors: Weber, J M, Cai, F, Horvath, J, Guillemette, J G
Format: Article
Language:English
Subjects:
Adenoviridae - chemistry
adenovirus
Adenovirus E2 Proteins - chemistry
Amino Acid Sequence
Animals
Deoxyribonucleases, Type II Site-Specific
Mice
Molecular Sequence Data
Protein Structure, Secondary
Sequence Homology, Amino Acid
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Summary:The DNA sequence of a portion of the MAV1 SmaI-D fragment coding for the C-terminal 147 amino acids of the adenoviral DNA-binding protein (DBP) has been determined. A multiple sequence alignment was constructed of the MAV1 fragment and the DBPs of Ad.2, 4, 5, 7, 12, 40, and 41 to examine the degree of conservation of features that have been mapped on the Ad.2 DBP and to identify further conserved features. The less conserved N-terminal segment of the protein contains two nuclear localization signals and two acidic regions, the host range region, and all of the 11 phosphorylation sites. The highly conserved C-terminal segment contains a potential leucine zipper and zinc finger motifs. These sequence features were mapped onto a predicted secondary structure of the Ad.2 DBP.
ISSN:0920-8569
1572-994X
DOI:10.1007/BF01702660