A single-injection, two-sample method for measuring renal 99mTc-MAG3 clearance in both children and adults

We present a method for estimating 99mTc-MAG3 clearance from both a single injection and two blood samples that is valid for both adults and children. It was obtained by fitting a scaled two-compartment model (having only two adjustable parameters) to adult and pediatric data from multiple centers.

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Bibliographic Details
Published in:Nuclear medicine and biology 1995, Vol.22 (1), p.55-60
Main Authors: RUSSELL, C. D, TAYLOR, A. T, DUBOVSKY, E. V, ESHIMA, D
Format: Article
Language:English
Subjects:
Adolescent
Adult
Biological and medical sciences
Child
Child, Preschool
Contrast media. Radiopharmaceuticals
Humans
Infant
Kidney - metabolism
Medical sciences
Metabolic Clearance Rate
Pharmacology. Drug treatments
Technetium Tc 99m Mertiatide - pharmacokinetics
Technetium Tc 99m Pentetate - pharmacokinetics
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Description
Summary:We present a method for estimating 99mTc-MAG3 clearance from both a single injection and two blood samples that is valid for both adults and children. It was obtained by fitting a scaled two-compartment model (having only two adjustable parameters) to adult and pediatric data from multiple centers.
ISSN:0969-8051
1872-9614
DOI:10.1016/0969-8051(94)00076-V