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Acyl-CoA synthetase activity depends on the phospholipid composition of rat liver plasma membranes
The dependence of acyl-CoA synthetase on the lipid composition of rat liver plasma membranes has been investigated. For this purpose the composition of the membranes was modified by incorporation of different phospholipids in the presence of partially purified lipid transfer proteins. Another approa...
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Published in: | Journal of lipid mediators and cell signalling 1995, Vol.11 (1), p.13-23 |
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container_title | Journal of lipid mediators and cell signalling |
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creator | Momchilova-Pankov, Albena B. Markovska, Tania T. Koumanov, Kamen S. |
description | The dependence of acyl-CoA synthetase on the lipid composition of rat liver plasma membranes has been investigated. For this purpose the composition of the membranes was modified by incorporation of different phospholipids in the presence of partially purified lipid transfer proteins. Another approach to the modification of the membrane phospholipid composition was treatment with exogenous phospholipase C and subsequent enrichment with different phospholipids. The experiments performed in vitro indicated that the presence of certain phospholipids such as phosphatidylnositol, phosphatidylethanolamine, phosphatidylglycerol and phosphatidylserine was essential for the activation of long chain fatty acids by aryl-CoA synthetase. However, some differences were observed when oleate and palmitate were used as substrates. Sphingomyelin was found to inhibit this activity especially when oleic acid served as substrate. In addition, we tried to modify in vivo the membrane lipid composition by treatment with n-galactosamine, which is known to induce acute hepatitis and cause biochemical and biophysical alterations in liver membranes. The results thus obtained confirmed the idea that the augmentation of the membrane lipids and especially of PI, PE and PG was accompanied by acyl-CoA synthetase activation. The presence of two different enzymes, activating the saturated and unsaturated fatty acids is discussed. |
doi_str_mv | 10.1016/0929-7855(94)00024-7 |
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For this purpose the composition of the membranes was modified by incorporation of different phospholipids in the presence of partially purified lipid transfer proteins. Another approach to the modification of the membrane phospholipid composition was treatment with exogenous phospholipase C and subsequent enrichment with different phospholipids. The experiments performed in vitro indicated that the presence of certain phospholipids such as phosphatidylnositol, phosphatidylethanolamine, phosphatidylglycerol and phosphatidylserine was essential for the activation of long chain fatty acids by aryl-CoA synthetase. However, some differences were observed when oleate and palmitate were used as substrates. Sphingomyelin was found to inhibit this activity especially when oleic acid served as substrate. In addition, we tried to modify in vivo the membrane lipid composition by treatment with n-galactosamine, which is known to induce acute hepatitis and cause biochemical and biophysical alterations in liver membranes. The results thus obtained confirmed the idea that the augmentation of the membrane lipids and especially of PI, PE and PG was accompanied by acyl-CoA synthetase activation. The presence of two different enzymes, activating the saturated and unsaturated fatty acids is discussed.</description><identifier>ISSN: 0929-7855</identifier><identifier>DOI: 10.1016/0929-7855(94)00024-7</identifier><identifier>PMID: 7728415</identifier><language>eng</language><publisher>Netherlands: Elsevier B.V</publisher><subject>Acyl-CoA synthetase ; Animals ; Cell Membrane - drug effects ; Cell Membrane - enzymology ; Coenzyme A Ligases - metabolism ; d-Galactosamine ; Galactosamine - pharmacology ; Liver - enzymology ; Liver - ultrastructure ; Male ; Phospholipase C ; Phospholipids ; Phospholipids - metabolism ; Phospholipids - physiology ; Plasma membranes ; Rats ; Rats, Wistar ; Type C Phospholipases - metabolism ; Type C Phospholipases - pharmacology</subject><ispartof>Journal of lipid mediators and cell signalling, 1995, Vol.11 (1), p.13-23</ispartof><rights>1995</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c357t-87a3a7f174fbe95753e43f3233a55c81ef8b7d73d0bd1535994500769669283f3</citedby><cites>FETCH-LOGICAL-c357t-87a3a7f174fbe95753e43f3233a55c81ef8b7d73d0bd1535994500769669283f3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,4024,27923,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/7728415$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Momchilova-Pankov, Albena B.</creatorcontrib><creatorcontrib>Markovska, Tania T.</creatorcontrib><creatorcontrib>Koumanov, Kamen S.</creatorcontrib><title>Acyl-CoA synthetase activity depends on the phospholipid composition of rat liver plasma membranes</title><title>Journal of lipid mediators and cell signalling</title><addtitle>J Lipid Mediat Cell Signal</addtitle><description>The dependence of acyl-CoA synthetase on the lipid composition of rat liver plasma membranes has been investigated. For this purpose the composition of the membranes was modified by incorporation of different phospholipids in the presence of partially purified lipid transfer proteins. Another approach to the modification of the membrane phospholipid composition was treatment with exogenous phospholipase C and subsequent enrichment with different phospholipids. The experiments performed in vitro indicated that the presence of certain phospholipids such as phosphatidylnositol, phosphatidylethanolamine, phosphatidylglycerol and phosphatidylserine was essential for the activation of long chain fatty acids by aryl-CoA synthetase. However, some differences were observed when oleate and palmitate were used as substrates. Sphingomyelin was found to inhibit this activity especially when oleic acid served as substrate. In addition, we tried to modify in vivo the membrane lipid composition by treatment with n-galactosamine, which is known to induce acute hepatitis and cause biochemical and biophysical alterations in liver membranes. The results thus obtained confirmed the idea that the augmentation of the membrane lipids and especially of PI, PE and PG was accompanied by acyl-CoA synthetase activation. The presence of two different enzymes, activating the saturated and unsaturated fatty acids is discussed.</description><subject>Acyl-CoA synthetase</subject><subject>Animals</subject><subject>Cell Membrane - drug effects</subject><subject>Cell Membrane - enzymology</subject><subject>Coenzyme A Ligases - metabolism</subject><subject>d-Galactosamine</subject><subject>Galactosamine - pharmacology</subject><subject>Liver - enzymology</subject><subject>Liver - ultrastructure</subject><subject>Male</subject><subject>Phospholipase C</subject><subject>Phospholipids</subject><subject>Phospholipids - metabolism</subject><subject>Phospholipids - physiology</subject><subject>Plasma membranes</subject><subject>Rats</subject><subject>Rats, Wistar</subject><subject>Type C Phospholipases - metabolism</subject><subject>Type C Phospholipases - pharmacology</subject><issn>0929-7855</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1995</creationdate><recordtype>article</recordtype><recordid>eNp9kMtKAzEUhrNQvFTfQCEr0cVoMkmayUYoxRsIbnQdMskZjMxMxiQt9O1NbXHp4nDg_P-5fQhdUHJLCZ3fEVWrSjZCXCt-QwipeSUP0Mlf-RidpvRFCJWkEUfoSMq64VScoHZhN321DAucNmP-hGwSYGOzX_u8wQ4mGF3CYcRFw9NnSCV6P3mHbRimkHz2RQwdjibj3q8h4qk3aTB4gKGNZoR0hg470yc43-cZ-nh8eF8-V69vTy_LxWtlmZC5aqRhRnZU8q4FJaRgwFnHasaMELah0DWtdJI50joqmFCKC0LkXM3nqm6Kc4audnOnGL5XkLIefLLQ9-WIsEq6_MwbKmkx8p3RxpBShE5P0Q8mbjQleotTb7npLTetuP7FqWVpu9zPX7UDuL-mPcui3-90KE-uPUSdrIfRgvMRbNYu-P8X_ADcXoac</recordid><startdate>1995</startdate><enddate>1995</enddate><creator>Momchilova-Pankov, Albena B.</creator><creator>Markovska, Tania T.</creator><creator>Koumanov, Kamen S.</creator><general>Elsevier B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>1995</creationdate><title>Acyl-CoA synthetase activity depends on the phospholipid composition of rat liver plasma membranes</title><author>Momchilova-Pankov, Albena B. ; Markovska, Tania T. ; Koumanov, Kamen S.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c357t-87a3a7f174fbe95753e43f3233a55c81ef8b7d73d0bd1535994500769669283f3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1995</creationdate><topic>Acyl-CoA synthetase</topic><topic>Animals</topic><topic>Cell Membrane - drug effects</topic><topic>Cell Membrane - enzymology</topic><topic>Coenzyme A Ligases - metabolism</topic><topic>d-Galactosamine</topic><topic>Galactosamine - pharmacology</topic><topic>Liver - enzymology</topic><topic>Liver - ultrastructure</topic><topic>Male</topic><topic>Phospholipase C</topic><topic>Phospholipids</topic><topic>Phospholipids - metabolism</topic><topic>Phospholipids - physiology</topic><topic>Plasma membranes</topic><topic>Rats</topic><topic>Rats, Wistar</topic><topic>Type C Phospholipases - metabolism</topic><topic>Type C Phospholipases - pharmacology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Momchilova-Pankov, Albena B.</creatorcontrib><creatorcontrib>Markovska, Tania T.</creatorcontrib><creatorcontrib>Koumanov, Kamen S.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of lipid mediators and cell signalling</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Momchilova-Pankov, Albena B.</au><au>Markovska, Tania T.</au><au>Koumanov, Kamen S.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Acyl-CoA synthetase activity depends on the phospholipid composition of rat liver plasma membranes</atitle><jtitle>Journal of lipid mediators and cell signalling</jtitle><addtitle>J Lipid Mediat Cell Signal</addtitle><date>1995</date><risdate>1995</risdate><volume>11</volume><issue>1</issue><spage>13</spage><epage>23</epage><pages>13-23</pages><issn>0929-7855</issn><abstract>The dependence of acyl-CoA synthetase on the lipid composition of rat liver plasma membranes has been investigated. For this purpose the composition of the membranes was modified by incorporation of different phospholipids in the presence of partially purified lipid transfer proteins. Another approach to the modification of the membrane phospholipid composition was treatment with exogenous phospholipase C and subsequent enrichment with different phospholipids. The experiments performed in vitro indicated that the presence of certain phospholipids such as phosphatidylnositol, phosphatidylethanolamine, phosphatidylglycerol and phosphatidylserine was essential for the activation of long chain fatty acids by aryl-CoA synthetase. However, some differences were observed when oleate and palmitate were used as substrates. Sphingomyelin was found to inhibit this activity especially when oleic acid served as substrate. In addition, we tried to modify in vivo the membrane lipid composition by treatment with n-galactosamine, which is known to induce acute hepatitis and cause biochemical and biophysical alterations in liver membranes. The results thus obtained confirmed the idea that the augmentation of the membrane lipids and especially of PI, PE and PG was accompanied by acyl-CoA synthetase activation. The presence of two different enzymes, activating the saturated and unsaturated fatty acids is discussed.</abstract><cop>Netherlands</cop><pub>Elsevier B.V</pub><pmid>7728415</pmid><doi>10.1016/0929-7855(94)00024-7</doi><tpages>11</tpages></addata></record> |
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subjects | Acyl-CoA synthetase Animals Cell Membrane - drug effects Cell Membrane - enzymology Coenzyme A Ligases - metabolism d-Galactosamine Galactosamine - pharmacology Liver - enzymology Liver - ultrastructure Male Phospholipase C Phospholipids Phospholipids - metabolism Phospholipids - physiology Plasma membranes Rats Rats, Wistar Type C Phospholipases - metabolism Type C Phospholipases - pharmacology |
title | Acyl-CoA synthetase activity depends on the phospholipid composition of rat liver plasma membranes |
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