β 2-Microglobulin: A Prognostic Parameter for Graft Survival after Renal Transplantation

The determination of β 2-microglobulin has recently been proposed as a promising diagnostic method to monitor the state of renal allografts. Elevated levels of β 2MG in the serum and/or urine allow the substantiation of the diagnosis of an acute graft rejection and are helpful in distinguishing acut...

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Bibliographic Details
Published in:Immunobiology (1979) 1986-10, Vol.173 (1), p.56-62
Main Authors: König, P., Spielberger, M., Kathrein, H., Margreiter, R.
Format: Article
Language:English
Subjects:
Adolescent
Adult
beta 2-Microglobulin - blood
beta 2-Microglobulin - urine
Female
Graft Rejection - drug effects
Graft Survival
Humans
Immunosuppression
Kidney Transplantation
Male
Middle Aged
Prognosis
Reference Values
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Summary:The determination of β 2-microglobulin has recently been proposed as a promising diagnostic method to monitor the state of renal allografts. Elevated levels of β 2MG in the serum and/or urine allow the substantiation of the diagnosis of an acute graft rejection and are helpful in distinguishing acute tubular necrosis from a rejection reaction (1). In this paper, the usefulness of β 2MG serum levels is evaluated, not only during the immediate post-operation phase but also for the long-term prognosis of renal allografts. The immunosuppression treatment included methylprednisolone and azathioprine in all the presented patients. The data indicate that a rapid normalization of β 2MGSL within 6 days, even if the decrease is interrupted by reelevation due to acute rejection episodes or inflammatory diseases, represents a good longterm prognosis for kidney allografts.
ISSN:0171-2985
1878-3279
DOI:10.1016/S0171-2985(86)80089-4