BACTERIOLOGICAL AND CLINICAL STUDY ON CIPROFLOXACIN IN GONOCOCCAL URETHRITIS

The purpose of this study was to determine the susceptibility of Neisseria gonorrhoeae to ciprofloxacin (CPFX). The MIC's of CPFX against 50 clinical isolates of N. gonorrhoeae was examined and they were between 50. 003μg/ml and 0. 006μ g/ml including 8β-lactamase producing strains. The CPFX wa...

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Bibliographic Details
Published in:Japanese journal of antibiotics 1986/10/25, Vol.39(10), pp.2685-2689
Main Authors: OKAZAKI, TAKEJIRO, KIYOTA, HIROSHI, GOTOH, HIROKAZU, ONODERA, SHOICHI
Format: Article
Language:Japanese
Subjects:
Administration, Oral
Adult
Ciprofloxacin - pharmacology
Ciprofloxacin - therapeutic use
Drug Resistance, Microbial
Gonorrhea - drug therapy
Humans
Male
Middle Aged
Neisseria gonorrhoeae - drug effects
Urethritis - drug therapy
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Summary:The purpose of this study was to determine the susceptibility of Neisseria gonorrhoeae to ciprofloxacin (CPFX). The MIC's of CPFX against 50 clinical isolates of N. gonorrhoeae was examined and they were between 50. 003μg/ml and 0. 006μ g/ml including 8β-lactamase producing strains. The CPFX was administered orally to 3 groups of 10 cases with gonococcal urethritis, groups being determined by 3 dose levels: a group with 200mg b. i. d. for 3 days (a total of 1, 200 mg), another with 400 mg b. i. d.(a total of 800 mg) and the final group with single administration of 400 mg. The effect of CPFX in the 1,200 mg-administered group was excellent in 3 and good in 7. The effect of the drug in the 800 mg-administered group was excellent in 2 and good in 8. The effect in the 400 mgadministered group was all good. Therefore, the overall cure rate was 100% including 5 patients with β-lactamase producing gonococcic infection. Side effects were not observed in the 30 cases.
ISSN:0368-2781
2186-5477
DOI:10.11553/antibiotics1968b.39.2685