Old phage, new insights: Two recently recognized mechanisms of transcriptional regulation in bacteriophage T4 development

The regulation of bacteriophage T4 middle and late gene expression involves previously unrecognized mechanisms. Middle transcription requires a DNA‐binding transcriptional activator and a σ70‐binding co‐activator. The coupling of late transcription to DNA replication is effected by a DNA‐tracking pr...

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Bibliographic Details
Published in:FEMS microbiology letters 1995-04, Vol.128 (1), p.1-8
Main Authors: Brody, E.N, Kassavetis, G.A, Ouhammouch, M, Sanders, G.M, Tinker, R.L, Geiduschek, E.P
Format: Article
Language:English
Subjects:
Anti‐sigma
Bacteriophage T4
Bacteriophage T4 - genetics
Bacteriophage T4 - physiology
Base Sequence
Biological and medical sciences
Co‐activators
DNA Replication
DNA, Viral - physiology
DNA‐tracking proteins
Fundamental and applied biological sciences. Psychology
Gene Expression Regulation, Viral
Genetics
Microbiology
Molecular Sequence Data
phage T4
Promoter Regions, Genetic - physiology
Replication‐transcription coupling
Transcription, Genetic - genetics
Transcription, Genetic - physiology
Transcriptional regulation
Virology
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Summary:The regulation of bacteriophage T4 middle and late gene expression involves previously unrecognized mechanisms. Middle transcription requires a DNA‐binding transcriptional activator and a σ70‐binding co‐activator. The coupling of late transcription to DNA replication is effected by a DNA‐tracking protein that is loaded onto DNA by an assembly factor at enhancer‐like entry sites. Late transcription also requires an RNA polymerase core‐binding co‐activator. The co‐activators of T4 middle and late transcription share the property of depressing unactivated, basal transcription.
ISSN:0378-1097
1574-6968
DOI:10.1111/j.1574-6968.1995.tb07491.x