Vitamin D and pubertal maturation. Value and tolerance of vitamin D supplementation during the winter season

In France, several cases of vitamin D-deficiency rickets among adolescents have been reported, but no prophylaxis measure has been systematically recommended at this age. The aim of this study was to measure 25-hydroxyvitamin D (25-(OH)D) levels and to search for biological signs of vitamin D defici...

Full description

Saved in:
Bibliographic Details
Published in:Archives de pédiatrie : organe officiel de la Société française de pédiatrie 1995-03, Vol.2 (3), p.221-226
Main Authors: Zeghoud, F, Delaveyne, R, Rehel, P, Chalas, J, Garabédian, M, Odièvre, M
Format: Article
Language:fre
Subjects:
Adolescent
Alkaline Phosphatase - metabolism
Calcitriol - blood
Calcium - blood
Child
Female
Food, Fortified
Humans
Hydroxycholecalciferols - blood
Male
Parathyroid Hormone - blood
Phosphates - blood
Puberty - blood
Seasons
Sexual Maturation
Vitamin D - pharmacology
Vitamin D - therapeutic use
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:In France, several cases of vitamin D-deficiency rickets among adolescents have been reported, but no prophylaxis measure has been systematically recommended at this age. The aim of this study was to measure 25-hydroxyvitamin D (25-(OH)D) levels and to search for biological signs of vitamin D deficiency during adolescence. Moreover, the effects of a unique oral dose of 100,000 IU of vitamin D3, given during the winter, were analysed. Circulating levels of 25-(OH)D, 1,25-dihydroxyvitamin D, intact parathyroid hormone (iPTH), alkaline phosphatase activities, calcium and phosphate were measured in 53 adolescents aged 10-17 years (81% of metropolitan origin), seen during the winter. The effect of a single oral dose of 100,000 IU of vitamin D3 or of placebo was studied in 15 of these subjects. 24.5% of the adolescents had low 25-(OH)D concentrations (< 6 ng/ml), this frequency being even more elevated (38%) at the end of pubertal maturation (stages 4 and 5). An increase in iPTH concentrations was found in subjects with lowest 25-(OH)D levels (< 3 ng/ml). An oral dose of 100,000 IU of vitamin D3 resulted in a significant increase in the 25-(OH)D levels; yet, these levels remained within the normal range during the 1-2 month follow-up of the nine treated subjects. This dosage made it possible to correct the low calcium concentrations (2.20-2.24 mmol/l) found before treatment in three adolescents. The high frequency of low vitamin D status observed during puberty and its normalization after a 100,000 IU vitamin D3 supplementation show the interest and safety of this intermittent 100,000 IU vitamin D3 supplementation to adolescents during the winter season.
ISSN:0929-693X