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Rhabdomyolysis Associated with Acute Varicella Infection

We report two cases of intense, generalized rhabdomyolysis complicating varicella-zoster virus (VZV) infections, one in an adolescent and one in a young adult male. In both cases, myoglobinuria and weakness of large muscle groups developed within 5 days of the onset of vesicular lesions. A muscle bi...

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Bibliographic Details
Published in:Clinical infectious diseases 1995-02, Vol.20 (2), p.450-453
Main Authors: Pratt, R. Douglas, Bradley, John S., Loubert, Cheryl, LaRocco, Anthony, McNeal, Richard M., Newbury, Robert O., Sawyer, Mark H.
Format: Article
Language:English
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Summary:We report two cases of intense, generalized rhabdomyolysis complicating varicella-zoster virus (VZV) infections, one in an adolescent and one in a young adult male. In both cases, myoglobinuria and weakness of large muscle groups developed within 5 days of the onset of vesicular lesions. A muscle biopsy from one of the individuals showed muscle fiber necrosis in the absence of acute inflammatory infiltrates or vasculitis. Culture of the muscle biopsy specimen for VZV was negative; however, the VZV genome was detected by the polymerase chain reaction. Both patients recovered fully after treatment with hydration therapy alone.
ISSN:1058-4838
1537-6591
DOI:10.1093/clinids/20.2.450