Poliovirus infection without accumulation of eclipse particles

Poliovirus type 1 (Mahoney) was treated with the capsid-binding pyridazinamine R 78206, followed by dialysis to remove free compound. Upon infection of HeLa cells by R 78206-pretreated virus, the formation of intra- and extracellular modified particles was completely inhibited, except for a small am...

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Bibliographic Details
Published in:Antiviral research 1995, Vol.26 (1), p.27-35
Main Authors: Ofori-Anyinam, Opokua, Vrijsen, Raf, Kronenberger, Peter, Boeyé, Albert
Format: Article
Language:English
Subjects:
Antibiotics. Antiinfectious agents. Antiparasitic agents
Antiviral
Antiviral agents
Antiviral Agents - therapeutic use
Biological and medical sciences
Capsid - drug effects
Capsid - metabolism
Capsid - physiology
Eclipse particle
HeLa Cells - virology
Humans
Medical sciences
Pharmacology. Drug treatments
Piperidines - therapeutic use
Poliomyelitis - drug therapy
Poliomyelitis - prevention & control
Poliomyelitis - virology
Poliovirus
Poliovirus - drug effects
Poliovirus - metabolism
Poliovirus - physiology
Pyridazines - therapeutic use
R 78206
Viral Proteins - biosynthesis
Virion - drug effects
Virion - metabolism
Virion - physiology
Virus Replication - drug effects
Virus Replication - physiology
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Summary:Poliovirus type 1 (Mahoney) was treated with the capsid-binding pyridazinamine R 78206, followed by dialysis to remove free compound. Upon infection of HeLa cells by R 78206-pretreated virus, the formation of intra- and extracellular modified particles was completely inhibited, except for a small amount of empty capsids. The synthesis of viral proteins and first cycle progeny virus was delayed by 1 h. The results suggest that poliovirus infection does not require intracellular accumulation of 135 S eclipse particles.
ISSN:0166-3542
1872-9096
DOI:10.1016/0166-3542(94)00063-E