Efficacy of ofloxacin in uncomplicated gonorrhoea

A randomised double blind trial comparing single oral dose therapy with 200 mg and 400 mg of ofloxacin, respectively was conducted at the Bangrak Hospital, Bangkok during the period December 6, 1985 to January 24, 1986. We treated 234 male patients diagnosed as having uncomplicated gonococcal urethr...

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Bibliographic Details
Published in:Infection 1986-01, Vol.14 (S4), p.S311-S313
Main Authors: ARIYARIT, C, PANIKABUTRA, K, CHITWARAKORN, A, WONGBA, C, BUATIANG, A
Format: Article
Language:English
Subjects:
Anti-Infective Agents - administration & dosage
Anti-Infective Agents - therapeutic use
Antibacterial agents
Antibiotics. Antiinfectious agents. Antiparasitic agents
Biological and medical sciences
Clinical Trials as Topic
Double-Blind Method
Gonorrhea - drug therapy
Humans
Male
Medical sciences
Ofloxacin
Oxazines - administration & dosage
Oxazines - therapeutic use
Pharmacology. Drug treatments
Random Allocation
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Summary:A randomised double blind trial comparing single oral dose therapy with 200 mg and 400 mg of ofloxacin, respectively was conducted at the Bangrak Hospital, Bangkok during the period December 6, 1985 to January 24, 1986. We treated 234 male patients diagnosed as having uncomplicated gonococcal urethritis with ofloxacin. Ofloxacin, at a single dose of 200 mg or 400 mg, was given to each of them. Fourteen patients were excluded for efficacy assessment. There were 223 patients left for safety assessment. The cure rates were 100% in both groups. Among 233 isolates tested, 48.5% were penicillinase producing Neisseria gonorrhoeae. The range of minimum inhibitory concentrations of ofloxacin was 0.008 to 0.063 mg/l. No adverse drug experiences were reported.
ISSN:0300-8126
1439-0973
DOI:10.1007/BF01661304