Chronic ethanol ingestion alters parameters of mid-latency auditory evoked potentials in male rats

The purpose of this study was to determine the effects of chronic ethanol ingestion on components of mid-latency auditory evoked potentials (MAEPs). Male Sprague-Dawley rats were administered 10% ethanol in drinking water for 10 months. MAEPs were obtained and compared to age-matched controls provid...

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Bibliographic Details
Published in:Alcohol (Fayetteville, N.Y.) N.Y.), 1995, Vol.12 (1), p.15-22
Main Authors: Floyd, E.A., Keaton, A.K., Clark, J.T., Rucker, H.K.
Format: Article
Language:English
Subjects:
Acoustic Stimulation
Alcoholism and acute alcohol poisoning
Animals
Biological and medical sciences
Electrophysiology
Ethanol
Ethanol - blood
Ethanol - pharmacology
Evoked Potentials, Auditory - drug effects
Female
Information processing
Male
Medical sciences
Mid-latency auditory evoked potentials
Pregnancy
Rats
Rats, Sprague-Dawley
Toxicology
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Summary:The purpose of this study was to determine the effects of chronic ethanol ingestion on components of mid-latency auditory evoked potentials (MAEPs). Male Sprague-Dawley rats were administered 10% ethanol in drinking water for 10 months. MAEPs were obtained and compared to age-matched controls provided tap water. Data were obtained for varying frequencies (4, 8, 16, 24, and 32 kHz) and intensities (65, 75, and 85 dB sound pressure level). Ethanol treatment was associated with increased latencies, as well as decreased amplitudes of Na and Pa. The effects were most prominent for MAEP component Pa, but also appear for component Na. We suggest that chronic alcohol consumption induces structural and/or neurochemical alterations in substrates for cortical information processing.
ISSN:0741-8329
1873-6823
DOI:10.1016/0741-8329(94)00061-H