Lack of circadian rhythm in plasma levels of 3,4-dihydroxyphenylethyleneglycol in healthy human subjects

In order to investigate the possible existence of a circadian rhythm in plasma free and sulfate-conjugated 3,4-dihydroxyphenylethyleneglycol (DOPEG), the plasma levels of this metabolite (and for comparison, of melatonin and cortisol) were measured in seven healthy volunteers at 4-h intervals over a...

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Published in:Psychopharmacologia 1986-01, Vol.90 (4), p.471-474
Main Authors: DENNIS, T, BENKELFAT, C, TOUITOU, Y, AUZEBY, A, POIRIER, M.-F, SCATTON, B, LOO, H
Format: Article
Language:English
Subjects:
Adult
Applied sciences
Biological and medical sciences
Chronobiology
Circadian Rhythm
Exact sciences and technology
Fundamental and applied biological sciences. Psychology
Glycols - blood
Humans
Hydrocortisone - blood
Male
Melatonin - blood
Methoxyhydroxyphenylglycol - analogs & derivatives
Methoxyhydroxyphenylglycol - blood
Other techniques and industries
Vertebrates: anatomy and physiology, studies on body, several organs or systems
Citations: Items that cite this one
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Summary:In order to investigate the possible existence of a circadian rhythm in plasma free and sulfate-conjugated 3,4-dihydroxyphenylethyleneglycol (DOPEG), the plasma levels of this metabolite (and for comparison, of melatonin and cortisol) were measured in seven healthy volunteers at 4-h intervals over a period of 24 h. Plasma concentrations of melatonin and cortisol showed distinct diurnal variations with acrophases at 2.5 h and 8.5 h, respectively. In contrast, plasma free DOPEG levels were relatively stable over the 24-h period studied. Sulfate-conjugated and free + sulfate-conjugated DOPEG levels showed a slight, non-significant increase in the early afternoon. These results indicate that in contrast to plasma 3-methoxy 4-hydroxyphenylethyleneglycol, plasma free and conjugated DOPEG levels do not exhibit a circadian rhythm.
ISSN:0033-3158
1432-2072
DOI:10.1007/BF00174063