Class II Major Histocompatibility Complex-Deficient Mice Initially Control an Infection with Leishmania major but Succumb to the Disease

Class II major histocompatibility complex (MHC)-deficient (H-2b) mice do not express I-A or I-E molecules and, as a result, do not develop CD4 cells. Thus, they represent the ideal model for examining the importance of CD4 cells and MHC class II molecules in resistance to infection with Leishmania m...

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Bibliographic Details
Published in:The Journal of infectious diseases 1995-05, Vol.171 (5), p.1302-1308
Main Authors: Chakkalath, Hrishekesh R., Theodos, Cynthia M., Markowitz, Jay S., Grusby, Michael J., Glimcher, Laurie H., Titus, Richard G.
Format: Article
Language:English
Subjects:
AIDS/HIV
Animals
Biological and medical sciences
CD4-Positive T-Lymphocytes - immunology
CD8-Positive T-Lymphocytes - immunology
Cell lines
Cultured cells
Cutaneous leishmaniasis
Experimental protozoal diseases and models
Genes, MHC Class II - genetics
Histocompatibility Antigens Class II - immunology
Immunophenotyping
Infections
Infectious diseases
Interferon-gamma - biosynthesis
Leishmania major
Leishmania major - growth & development
Leishmaniasis, Cutaneous - immunology
Leishmaniasis, Cutaneous - parasitology
Lesions
Lymph Nodes - cytology
Lymph Nodes - metabolism
Lymphocyte Activation
Macrophages
Major Articles
Medical sciences
Mice
Mice, Inbred C57BL
Molecules
Mutation - physiology
Parasites
Parasitic diseases
Protozoal diseases
Receptors, Antigen, T-Cell, alpha-beta - analysis
T lymphocytes
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Summary:Class II major histocompatibility complex (MHC)-deficient (H-2b) mice do not express I-A or I-E molecules and, as a result, do not develop CD4 cells. Thus, they represent the ideal model for examining the importance of CD4 cells and MHC class II molecules in resistance to infection with Leishmania major and the capacity of MHC class I-restricted T cells to mediate resistance to L. major. Class II MHC-deficient mice and control (C57BL/6, normal and nude) mice were infected with L. major. Although MHC class II-deficient mice were able to control infection more effectively than nude mice, cutaneous lesions on the mice eventually progressed, and parasite replication became uncontrolled. These results suggest that CD4 cells and MHC class II molecules are essential for resistance to L. major and that in the absence of these cells and molecules, such mice can transiently control infection with L. major but are unable to resolve such infections.
ISSN:0022-1899
1537-6613
DOI:10.1093/infdis/171.5.1302