Single dose ofloxacin in treatment of uncomplicated gonorrhoea

78 patients (66 male and 12 female) suffering from uncomplicated gonorrhoea were randomly selected to receive a single oral dose of either 400 mg or 600 mg ofloxacin. Of the 59 patients completely followed up penicillinase-producing Neisseria gonorrhoeae strains were cultured in 15 (25.4%) and the o...

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Bibliographic Details
Published in:Infection 1986-01, Vol.14 (S4), p.S314-S315
Main Authors: CHAN, A. S. C, TANG, K. C, FUNG, K. K, NG, T. K
Format: Article
Language:English
Subjects:
Adult
Anti-Infective Agents - administration & dosage
Anti-Infective Agents - therapeutic use
Antibacterial agents
Antibiotics. Antiinfectious agents. Antiparasitic agents
Biological and medical sciences
Clinical Trials as Topic
Female
Gonorrhea - drug therapy
Humans
Male
Medical sciences
Ofloxacin
Oxazines - administration & dosage
Oxazines - therapeutic use
Pharmacology. Drug treatments
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Summary:78 patients (66 male and 12 female) suffering from uncomplicated gonorrhoea were randomly selected to receive a single oral dose of either 400 mg or 600 mg ofloxacin. Of the 59 patients completely followed up penicillinase-producing Neisseria gonorrhoeae strains were cultured in 15 (25.4%) and the overall cure rate was 100%. Both groups showed excellent clinical effectiveness in over 80% and adverse reactions were uncommon and transient. We conclude that a single oral dose of ofloxacin in the studied dosage regimens was highly effective and safe in the treatment of uncomplicated gonorrhoea.
ISSN:0300-8126
1439-0973
DOI:10.1007/BF01661305