I-131 MIBG scintigraphy of neuroectodermal tumors: comparison between I-131 MIBG and In-111 DTPA octreotide

An account is given of the results observed with I-131 MIBG scintigraphy in four patients (1 bladder pheochromocytoma, 3 neuroblastomas) chosen on account of their particular clinical and diagnostic interest from a series of 41 apudoma patients examined by means of this technique. In the first patie...

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Bibliographic Details
Published in:Clinical nuclear medicine 1995-03, Vol.20 (3), p.243-249
Main Authors: LAURIERO, F, RUBINI, G, D'ADDABBO, F, RUBINI, D, SCHETTINI, F, D'ADDABBO, A
Format: Article
Language:English
Subjects:
3-Iodobenzylguanidine
Adolescent
Adrenal Gland Neoplasms - diagnostic imaging
Biological and medical sciences
Child, Preschool
Humans
Indium Radioisotopes
Infant
Investigative techniques, diagnostic techniques (general aspects)
Iodine Radioisotopes
Iodobenzenes
Medical sciences
Nervous system
Neuroblastoma - congenital
Neuroblastoma - diagnostic imaging
Neuroblastoma - secondary
Octreotide - analogs & derivatives
Pentetic Acid - analogs & derivatives
Pheochromocytoma - diagnostic imaging
Radionuclide Imaging
Radionuclide investigations
Thoracic Neoplasms - diagnostic imaging
Urinary Bladder Neoplasms - diagnostic imaging
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Summary:An account is given of the results observed with I-131 MIBG scintigraphy in four patients (1 bladder pheochromocytoma, 3 neuroblastomas) chosen on account of their particular clinical and diagnostic interest from a series of 41 apudoma patients examined by means of this technique. In the first patient, the unusual site of the tumor in the posterior wall of the bladder meant that its detection by I-131 MIBG was only possible after catheterization of the bladder. In the second patient, uptake in the metastasis was only evident after removal of the primary tumor. In the third patient, the scintiscan revealed several metastases (some in bone) not detected by CT. In the fourth patient (congenital neuroblastoma), enhanced uptake accompanied the appearance of high plasma catecholamine and urinary vanillylhandelic acid values, suggesting a functional switch from a nonsecreting to a secreting form. a supplementary In-111 DTPA-Octreotide (OCT) scintiscan of this patient demonstrated the presence of somatostatin receptors on the neuroblasts. Thus, this examination would seem particularly useful for the differentiation of nonsecreting neuroblastomas. Its employment in assessment of the therapeutic capacity of OCT itself is also suggested.
ISSN:0363-9762
1536-0229
DOI:10.1097/00003072-199503000-00011