Determination of fractal dimension of physiologically characterized neurons in two and three dimensions

Although there is a growing interest in the application of fractal analysis in neurobiology, questions about the methodology have restricted its wider application. In this report we discuss some of the underlying principles for fractal analysis, we propose the cumulative-mass method as a standard me...

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Bibliographic Details
Published in:Journal of neuroscience methods 1995-02, Vol.56 (2), p.133-144
Main Authors: Caserta, F., Eldred, W.D., Fernandez, E., Hausman, R.E., Stanford, L.R., Bulderev, S.V., Schwarzer, S., Stanley, H.E.
Format: Article
Language:English
Subjects:
Animals
Biological and medical sciences
Cats
Cells - classification
Cumulative-mass method
Dendritic branching
Fractal dimension
Fractals
Fundamental and applied biological sciences. Psychology
Ganglia - physiology
General aspects. Models. Methods
Image Processing, Computer-Assisted
Neurons - physiology
Physiologically characterized neuron
Retina - physiology
Retinal ganglion cell
Sholl analysis
Vertebrates: nervous system and sense organs
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Summary:Although there is a growing interest in the application of fractal analysis in neurobiology, questions about the methodology have restricted its wider application. In this report we discuss some of the underlying principles for fractal analysis, we propose the cumulative-mass method as a standard method and we extend the applicability of fractal analysis to both 2 and 3 dimensions. We have examined the relationship between the method of log-log Sholl analysis and fractal analysis and have found that they correlate well. Measurements of physiologically characterized retinal ganglion cells indicate that different cell types can have significantly different fractal dimensions. Such differences may allow the correlation of the physiological type of a neuron with its morphological fractal dimension.
ISSN:0165-0270
1872-678X
DOI:10.1016/0165-0270(94)00115-W