Soft-tissue Uptake of Technetium-99m MDP in Multiple Myeloma

Abnormal accumulation of Tc-99m MDP in the lungs and stomach was observed in a patient with multiple myeloma and refractory hypercalcemia. There was no roentgenographic evidence of calcification. At postmortem examination, the presence of amyloid deposits was confirmed in both organs, while the corr...

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Bibliographic Details
Published in:Clinical nuclear medicine 1986-12, Vol.11 (12), p.878-879
Main Authors: KANOH, TADASHI, UCHINO, HARUTO, YAMAMOTO, ITSUO, TORIZUKA, KANJI
Format: Article
Language:English
Subjects:
Amyloidosis - complications
Amyloidosis - diagnostic imaging
Biological and medical sciences
Humans
Immunodeficiencies. Immunoglobulinopathies
Immunoglobulinopathies
Immunopathology
Male
Medical sciences
Middle Aged
Multiple Myeloma - complications
Multiple Myeloma - diagnostic imaging
Radionuclide Imaging
Technetium Tc 99m Medronate
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Summary:Abnormal accumulation of Tc-99m MDP in the lungs and stomach was observed in a patient with multiple myeloma and refractory hypercalcemia. There was no roentgenographic evidence of calcification. At postmortem examination, the presence of amyloid deposits was confirmed in both organs, while the corresponding metastatic calcification was demonstrated only in the gastric mucosa. It seems likely that, in our case, softtissue localization of bone-seeking agent was attributable to the presence of amyloid deposits rather than metastatic calcification. No cases showing the combined occurrence of amyloid deposition and metastatic calcification in soft-tissues have previously been demonstrated to concentrate bone-seeking agent.
ISSN:0363-9762
1536-0229
DOI:10.1097/00003072-198612000-00022