Investigation of some effects of levamisole on dog blood pressure

The effects of levamisole were investigated on the blood pressure of anaesthetized dog. Levamisole (0.5 to 4.0 mg/kg) elicited a biphasic effect, an initial brief depressor response followed by a pressor response. The pressor response was dose-related and was blocked by phenoxybenzamine. The residua...

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Published in:Indian journal of physiology and pharmacology 1986-01, Vol.30 (1), p.55-62
Main Authors: Shah, K K, Gulati, O D, Hemavathi, K G
Format: Article
Language:English
Subjects:
Adrenalectomy
Adrenergic beta-Antagonists - pharmacology
Animals
Blood Pressure - drug effects
Cocaine - pharmacology
Dexamethasone - pharmacology
Dogs
Female
Levamisole - pharmacology
Male
Nialamide - pharmacology
Norepinephrine - pharmacology
Pyrogallol - pharmacology
Reserpine - pharmacology
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container_title Indian journal of physiology and pharmacology
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creator Shah, K K
Gulati, O D
Hemavathi, K G
description The effects of levamisole were investigated on the blood pressure of anaesthetized dog. Levamisole (0.5 to 4.0 mg/kg) elicited a biphasic effect, an initial brief depressor response followed by a pressor response. The pressor response was dose-related and was blocked by phenoxybenzamine. The residual depressor response was blocked by propranolol. Repeated administration of a high dose of levamisole produced tachyphylaxis. The pressor response to levamisole was not modified by either reserpinization, acute bilateral adrenalectomy or pretreatment with cocaine, whereas pretreatment with dexamethasone, nialamide or pyroaallol shifted the dose-response curve to the right. Levamisole potentiated the pressor responses to noradrenaline, angiotensin and acetylcholine. The effects of levamisole are ascribed to inhibition of monoamine oxidase, catechol-O-methyl transferase, catecholamine uptake2 mechanism and cholinesterase.
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subjects Adrenalectomy
Adrenergic beta-Antagonists - pharmacology
Animals
Blood Pressure - drug effects
Cocaine - pharmacology
Dexamethasone - pharmacology
Dogs
Female
Levamisole - pharmacology
Male
Nialamide - pharmacology
Norepinephrine - pharmacology
Pyrogallol - pharmacology
Reserpine - pharmacology
title Investigation of some effects of levamisole on dog blood pressure
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