Chromosomal localization of the human prostanoid receptor gene family

• Published in: Genomics (San Diego, Calif.) Calif.), 1995-02, Vol.25 (3), p.740-742
• Main Authors: Duncan, A.M.V., Anderson, L.L., Funk, C.D., Abramovitz, M., Adam, M.
• Format: Article
• Language: English
• Subjects: Biological and medical sciences; chromosome 1; chromosome 19; Chromosome Mapping; Chromosomes, Human, Pair 1; Chromosomes, Human, Pair 12; Chromosomes, Human, Pair 15; Chromosomes, Human, Pair 19; Chromosomes, Human, Pair 5; Classical genetics, quantitative genetics, hybrids; Fundamental and applied biological sciences. Psychology; gene mapping; Genetics of eukaryotes. Biological and molecular evolution; Human; Humans; In Situ Hybridization; man; Multigene Family; prostaglandin receptors; Receptors, Prostaglandin - genetics; Receptors, Thromboxane - genetics
• ISSN: 0888-7543; 1089-8646
• DOI: 10.1016/0888-7543(95)80022-E

Prostaglandins (PGD 2, PGE 2, PGF 2α, and PGI 2) and thromboxane A 2 (TXA 2) are biologically active molecules derived from the metabolism of arachidonic acid by cyclooxygenases. They produce a wide variety of physiological and pathophysiological effects mediated through specific G protein-coupled cell surface receptors. In this study, we have mapped the chromosomal positions of the human genes that encode the PGE 2 receptor subtypes ( PTGER1, PTGER2, and PTGER3), the PGF 2α receptor ( PTGFR), the PGI 2 receptor ( PTGIR), and the TXA 2 receptor ( TBXA2R) using in situ hybridization. The PTGER1, TBXA2R, and PTGIR genes mapped to chromosome 19 at positions 19p13.1, 19p13.3, and 19q13.3, respectively. The PTGFR and PTGER3 genes mapped to chromosome 1 at positions 1p31.1 and 1p31.2, respectively, and PTGER2 gene mapped to chromosome band 5p13.1.