COMPARATIVE STUDIES OF ANTIMICROBIAL AGENTS AGAINST CAUSATIVE ORGANISMS ISOLATED FROM URINARY TRACT INFECTIONS (1984): I. SUSCEPTIBILITY DISTRIBUTION

• Published in: Japanese journal of antibiotics 1986/11/25, Vol.39(11), pp.2959-3006
• Main Authors: KOSAKAI, NOZOMU, KUMAMOTO, YOSHIAKI, SAKAI, SHIGERU, HIROSE, TAKAOKI, SHIGETA, SHIRO, SHIRAIWA, YASUO, MIURA, YUTAKA, OGATA, MASAHIRO, TAZAKI, HIROSHI, IRI, HISAMI, UCHIDA, HIROSHI, ANDO, YASUHIKO, FURUYA, HIROSHI, MATSUDA, SEIJI, SOEDA, NOBORU, YOKOMATSU, MAMORU, KITAGAWA, RYUICHI, HIKICHI, YOSHINAO, MIYAZAKI, NAOFUMI, HAYASHI, YASUYUKI, OGURI, TOYOKO, FURUSAWA, TARO, TAKEUCHI, YASUKO, TSUCHIDA, HIROMI, YAMASHITA, NOBUYUKI, OKAMOTO, YURUKO, YONEZU, SEIBUN, MAEHARA, KEIGO, IIDA, YUBE, SHIMOE, SHOJI, TANAKA, MICHIO, YAMAGUCHI, KEIZO, KUSANO, NOBUCHIKA, IGARI, JUN
• Format: Article
• Language: Japanese
• Subjects: Anti-Bacterial Agents - pharmacology; Drug Resistance, Microbial; Enterobacter - drug effects; Escherichia coli - drug effects; Humans; Pseudomonas aeruginosa - drug effects; Serratia - drug effects; Urinary Tract Infections - microbiology
• ISSN: 0368-2781; 2186-5477
• DOI: 10.11553/antibiotics1968b.39.2959

Our research group was engaged for 3 years (1979-1981) in a study on sensitivities to antibiotics of 4 bacterial groups including representative pathogenic bacteria found in cases of urinary tract infections; i.e. E. coli, Klebsiella spp., Citrobacter spp., and Proteus spp. Since 1982, all the bacterial strains isolated by our group from patients with urinary tract infections and deemed by doctors in charge as pathogens were sent to the Laboratory of Clinical Pathology of Juntendo University, where they were refixed and subjected to MIC determination. This is the third year of the new study. E. coli was detected most frequently from patients with urinary tract infections and the detection frequency was 28% (323/1, 153) this year (1984), whereas it was 35.3% (304/860) last year, showing a 7% decline from last year to this year. E. faecalis was next frequent organism (12.7% or 147/1, 153) followed by P. aeruginosa (10.8% or 124/1, 153). This order, however, was reversed from last year. Other pathogens, in a decreasing order of isolation frequencies following the above three, were as follows: Proteus spp.(9.5% or 109/1, 153), S. marcescens (6.2% or 71/1, 153), S. epidermidis (5.4% or 62/1, 153), K. pneumoniae (4.9% or 56/1, 153), Enterobacter spp.(2.4% or 28/1, 153) and Citrobacter spp.(2.3% or 27/1, 153). The results of the determination of the sensitivity of bacterial strains to the antibiotics are described below. 1. Of all the oral antibacterial and antibiotic agents used against E. coli, mecillinam (MPC), cefaclor (CCL) and pipemidic acid (PPA) proved to have high antibacterial potency, and their MIC90 (the concentration to inhibit growths of 90% of the objective bacteria) was 3.13μg/ml. The MIC90's of cefotiam (CTM), cefotaxime (CTX), ceftizoxime (CZX), cefmenoxime (CMX) and latamoxef (LMOX) were less than 0.39μg/ml. The MIC90's of cefmetazole (CMZ) and cefoperazone (CPZ) were invariably 1.56μg/ml. 2. K. pneumoniae was not sensitive to ampicillin (ABPC) and did not show much sensitivity to other oral antibacterial and antibiotic agents also. Of all the injectable preparations of antibiotics, cephem antibiotics of the third generation showed the most potent antibacterial effects against K. pneumoniae, and their MIC90's were lower than 0.10μg/ml for CZX, 0.20μg/ml for CTX, 0.39μg/ml for CMX, and 0.78μg/ml for LMOX, while MIC90's of CPZ was 6.25μg/ml, which was equal to that of CMZ. The MIC90, of CTM was 0.78μg/ml which was identical to that of LMOX. 3. Th