Taurine Transport in Chronically Stimulated Fast- and Slow-Twitch Muscles of the Rat

Indirect stimulation via the sciatic nerve, 10 or 100 Hz stimulus trains of 1 sec duration, applied every 3 sec, 8 hr/day for 1-4 weeks increased taurine concentration of the extensor digitorum longus (EDL, fast-twitch) muscle of the rat. The uptake of [3H]-taurine into the EDL and tibialis anterior...

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Bibliographic Details
Published in:Japanese Journal of Pharmacology 1986, Vol.42(3), pp.441-446
Main Authors: KIM, Bong Ki, BABA, Akemichi, IWATA, Heitaroh
Format: Article
Language:English
Subjects:
Animals
Applied sciences
Biological and medical sciences
Biological Transport
Electric Stimulation
Exact sciences and technology
Fundamental and applied biological sciences. Psychology
In Vitro Techniques
Muscle Contraction
Muscles - metabolism
Muscles - physiology
Other techniques and industries
Rats
Rats, Inbred Strains
Sciatic Nerve - physiology
Striated muscle. Tendons
Taurine - metabolism
Vertebrates: osteoarticular system, musculoskeletal system
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Description
Summary:Indirect stimulation via the sciatic nerve, 10 or 100 Hz stimulus trains of 1 sec duration, applied every 3 sec, 8 hr/day for 1-4 weeks increased taurine concentration of the extensor digitorum longus (EDL, fast-twitch) muscle of the rat. The uptake of [3H]-taurine into the EDL and tibialis anterior (TA, fast-twitch) muscle was also increased by the stimulation. Concentration and uptake of taurine in the soleus muscle (SL, slow-twitch) did not change by chronic 10 Hz stimulation. Taurine concentration in the SL muscle was significantly reduced by chronic 100 Hz stimulation. This study shows that chronic nerve stimulation increases the uptake of taurine in the fast-twitch muscles, but not in the slow-twitch muscle.
ISSN:0021-5198
1347-3506
DOI:10.1254/jjp.42.441