Chromosomal assignment and genomic structure of Il15

• Published in: Genomics (San Diego, Calif.) Calif.), 1995-02, Vol.25 (3), p.701-706
• Main Authors: Anderson, Dirk M., Johnson, Lisabeth, Glaccum, Moira B., Copeland, Neal G., Gilbert, Debra J., Jenkins, Nancy A., Valentine, Virginia, Kirstein, Mark N., Shapiro, David N., Morris, Stephan W., Grabstein, Kenneth, Cosman, David
• Format: Article
• Language: English
• Subjects: Amino Acid Sequence; Animals; Base Sequence; Biological and medical sciences; Cell Line; chromosome 4; chromosome 8; Chromosome Mapping; Chromosomes, Human, Pair 4; Classical genetics, quantitative genetics, hybrids; cloning; Female; fluorescence in situ hybridization; Fundamental and applied biological sciences. Psychology; Genetics of eukaryotes. Biological and molecular evolution; Genome; Humans; Hybrid Cells; In Situ Hybridization, Fluorescence; Interleukin-15; Interleukin-2 - genetics; Interleukins - genetics; lymphocytes T; Male; man; Mice; Mice, Inbred C57BL; Molecular Sequence Data; Vertebrata
• ISSN: 0888-7543; 1089-8646
• DOI: 10.1016/0888-7543(95)80013-C

Interleukin-15 (IL-15) is a novel cytokine whose effects on T-cell activation and proliferation are similar to those of interleukin-2 (IL-2), presumably because IL-15 utilizes the β and γ chains of the IL-2 receptor. Murine IL-15 cDNA and genomic clones were isolated and characterized. The murine Il15 gene was found to consist of eight exons spanning at least 34 kb and was localized to the central region of mouse chromosome 8 by interspecific backcross analysis. Intron positions in a partial human IL15 genomic clone were identical with positions of corresponding introns in the murine gene. The human IL15 gene was mapped to human chromosome 4q31 by fluorescence in situ hybridization.