Clinical relevance of cathepsin B-like enzyme activity and cysteine proteinase inhibitor in melanocytic tumours

We studied the relationship between cathepsin B (CB)-like enzyme activities and cysteine proteinase inhibitor (CPI) activities in lesions of human pigmented naevi (PN), primary melanomas (PM) and metastases/metastatic melanomas (MM). The CB-like enzyme activities in PM and MM were 2.5 and 6.8 times...

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Bibliographic Details
Published in:Archives of Dermatological Research 1995-02, Vol.287 (2), p.209-213
Main Authors: YOSHII, A, KAGESHITA, T, TSUSHIMA, H, ONO, T
Format: Article
Language:English
Subjects:
Adult
Aged
Aged, 80 and over
Biological and medical sciences
Cathepsin B - analysis
Cysteine Proteinase Inhibitors - analysis
Dermatology
Disease-Free Survival
Female
Humans
Male
Medical sciences
Melanoma - classification
Melanoma - enzymology
Melanoma - pathology
Melanoma - surgery
Middle Aged
Neoplasm Metastasis
Neoplasm Staging
Nevus, Pigmented - enzymology
Nevus, Pigmented - pathology
Nevus, Pigmented - surgery
Predictive Value of Tests
Skin Neoplasms - classification
Skin Neoplasms - enzymology
Skin Neoplasms - pathology
Skin Neoplasms - surgery
Tumors of the skin and soft tissue. Premalignant lesions
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Summary:We studied the relationship between cathepsin B (CB)-like enzyme activities and cysteine proteinase inhibitor (CPI) activities in lesions of human pigmented naevi (PN), primary melanomas (PM) and metastases/metastatic melanomas (MM). The CB-like enzyme activities in PM and MM were 2.5 and 6.8 times higher than in PN, respectively. The CB-like/CPI ratios in PM and MM were 1.9 and 11.6 times higher than in PN, respectively. CPI had the highest activity in PM and the lowest activity in MM. The disease-free interval of patients with a high CB-like enzyme activity (> or = 80 U/mg protein) and/or a high CB-like/CPI ratio (> or = 7) was shorter than that of patients with a low CB-like enzyme activity (< 80 U/mg protein) and/or a low CB-like/CPI ratio (< 7). Analysis of CB-like enzyme activity and/or the CB-like/CPI ratio may be useful in predicting the prognosis of human malignant melanoma.
ISSN:0340-3696
1432-069X
DOI:10.1007/BF01262334