Viral oncoprotein binding to pRB, p107, p130, and p300

The purpose of this review is to bring attention to some additional work in the tumor virus/tumor suppressor field which may have been overshadowed by reports describing adenovirus, SV40, and HPV oncoprotein binding to pRB and p53. The data reviewed herein provide further support for the model that...

Full description

Saved in:
Bibliographic Details
Published in:Virus Research 1995-02, Vol.35 (2), p.113-121
Main Authors: Ludlow, John W., Skuse, Gary R.
Format: Article
Language:English
Subjects:
Animals
Antigens, Polyomavirus Transforming - metabolism
DNA Tumor Viruses - metabolism
Growth regulatory protein
Humans
Nuclear Proteins - metabolism
Oncogene Proteins, Viral - metabolism
Oncoprotein
Phosphoproteins
Proteins - metabolism
Retinoblastoma Protein - metabolism
Retinoblastoma-Like Protein p107
Retinoblastoma-Like Protein p130
Trans-Activators
Transcription Factors - metabolism
Tumor suppressor gene
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:The purpose of this review is to bring attention to some additional work in the tumor virus/tumor suppressor field which may have been overshadowed by reports describing adenovirus, SV40, and HPV oncoprotein binding to pRB and p53. The data reviewed herein provide further support for the model that a commin mechanism by which DNA tumor viruses transform cells involves inactivation of cellular proteins which function as negative regulators of cell growth.
ISSN:0168-1702
1872-7492
DOI:10.1016/0168-1702(94)00094-S