Effects of in vitro ethanol and chronic ethanol consumption on the release of excitatory amino acids in the rat hippocampus

In CA1-CA3 hippocampal slices, in vitro ethanol (EtOH) (10–100 mM) evoked, as a function of EtOH concentration, a differential release of aspartate (Asp) and glutamate (Glu). Omission of Ca 2+ ions from the superfusion media completely abolished the EtOH-induced release of Asp but not that of Glu. I...

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Bibliographic Details
Published in:Brain research 1995-03, Vol.674 (1), p.104-106
Main Authors: Sepúlveda, César, Bustos, Gonzalo, Gysling, Katia, Seguel, Mario, Labarca, Rodrigo
Format: Article
Language:English
Subjects:
[ 3H]Noradrenaline release
Alcohol Drinking
Alcoholism and acute alcohol poisoning
Animals
Aspartate release
Aspartic Acid - metabolism
Biological and medical sciences
Ethanol
Ethanol - pharmacology
Glutamate release
Glutamic Acid - metabolism
Hippocampus
Hippocampus - metabolism
In Vitro Techniques
Male
Medical sciences
Norepinephrine - metabolism
Rats
Rats, Sprague-Dawley
Time Factors
Toxicology
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Summary:In CA1-CA3 hippocampal slices, in vitro ethanol (EtOH) (10–100 mM) evoked, as a function of EtOH concentration, a differential release of aspartate (Asp) and glutamate (Glu). Omission of Ca 2+ ions from the superfusion media completely abolished the EtOH-induced release of Asp but not that of Glu. In addition, at 20 mM, EtOH enhanced K +-evoked release only of Asp. Finally, delayed changes were observed on NMDA-evoked release of [ 3H]noradrenaline (NA) in the dentate gyrus (DG) after withdrawal from EtOH for 30 days.
ISSN:0006-8993
1872-6240
DOI:10.1016/0006-8993(95)00072-X