Enhanced sensitivity of skin fibroblasts from neurofibromatosis patients to transformation by the Kirsten murine sarcoma virus. A potential laboratory assay for individuals at risk of cancer

The present work describes a laboratory assay for individuals predisposed to cancer within NF pedigrees. The assay is based on the association between the increased sensitivity of human skin fibroblasts to transformation by the Kirsten murine sarcoma virus and predisposition to cancer in clinically...

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Bibliographic Details
Published in:Annals of the New York Academy of Sciences 1986, Vol.486, p.403-412
Main Authors: Frankel, J W, Bidot, P, Kopelovich, L
Format: Article
Language:English
Subjects:
Cell Transformation, Neoplastic
Cell Transformation, Viral
Fibroblasts
Genotype
Humans
Kirsten murine sarcoma virus - genetics
Mutation
Nervous System Neoplasms - genetics
Pedigree
Risk
Sarcoma Viruses, Murine - genetics
Skin Neoplasms - genetics
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Summary:The present work describes a laboratory assay for individuals predisposed to cancer within NF pedigrees. The assay is based on the association between the increased sensitivity of human skin fibroblasts to transformation by the Kirsten murine sarcoma virus and predisposition to cancer in clinically affected patients and in otherwise apparently healthy individuals within NF pedigrees. The more sensitive the cells are to transformation by KiMSV, the greater the probability that a person from whom such cells have been derived will develop cancer. The results show a strong correlation with the NF trait. Together with the clinical data this laboratory assay could, therefore, be used to ascertain the NF genotype.
ISSN:0077-8923
DOI:10.1111/j.1749-6632.1986.tb48093.x