Castration reduces vasopressin receptor binding in the hamster hypothalamus

A recently developed ligand with very high affinity and selectivity for the vasopressin (AVP) V 1a receptor subtype (i.e. [ 125I]Linear AVP antagonist ([ 125I]-LinAntag) was used to describe the distribution of AVP binding sites in the hamster brain, and to determine whether AVP receptor binding was...

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Bibliographic Details
Published in:Brain research 1995-03, Vol.674 (1), p.153-158
Main Authors: Johnson, Allan E., Barberis, Claude, Elliott Albers, H.
Format: Article
Language:English
Subjects:
Animals
Anterior hypothalamus
Arginine Vasopressin - antagonists & inhibitors
Arginine Vasopressin - metabolism
Autoradiography
Binding Sites
Biological and medical sciences
Cricetinae
Flank marking
Fundamental and applied biological sciences. Psychology
Hamster
Hormones and neuropeptides. Regulation
Hypothalamus - metabolism
Hypothalamus. Hypophysis. Epiphysis. Urophysis
Male
Medial preoptic area
Mesocricetus auratus
Orchiectomy
Receptors, Vasopressin - metabolism
Testosterone
Tissue Distribution
Vasopressin
Vertebrates: endocrinology
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Description
Summary:A recently developed ligand with very high affinity and selectivity for the vasopressin (AVP) V 1a receptor subtype (i.e. [ 125I]Linear AVP antagonist ([ 125I]-LinAntag) was used to describe the distribution of AVP binding sites in the hamster brain, and to determine whether AVP receptor binding was influenced by testicular hormones in sites involved in the regulation of steroid-dependent social behaviors. These studies demonstrated [ 125I]LinAntag binding in regions of the hamster brain which have not been previously identified with other AVP ligands. In addition, testicular hormones were found to alter [ 125I]LinAntag binding in two distinct regions, the posterior lateral preoptic-anterior lateral hypothalamic continuum and the posterior ventrolateral hypothalamic nucleus and adjacent tuberal area.
ISSN:0006-8993
1872-6240
DOI:10.1016/0006-8993(95)00010-N