Molecular chaperones in antigen presentation

As is the case with most proteins of the secretory pathway, the biogenesis of MHC class I and class II molecules occurs in association with molecular chaperones. Considerable progress has been made in identifying the chaperones involved and recent studies on two of these, calnexin and invariant chai...

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Bibliographic Details
Published in:Current opinion in immunology 1995-02, Vol.7 (1), p.77-84
Main Authors: Williams, David B, Watts, Tania H
Format: Article
Language:English
Subjects:
Animals
Antigen Presentation - immunology
Humans
Molecular Chaperones - immunology
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Summary:As is the case with most proteins of the secretory pathway, the biogenesis of MHC class I and class II molecules occurs in association with molecular chaperones. Considerable progress has been made in identifying the chaperones involved and recent studies on two of these, calnexin and invariant chain, have shown that they influence multiple processes including protein stability, folding, assembly and intercellular retention.
ISSN:0952-7915
1879-0372
DOI:10.1016/0952-7915(95)80032-8